The recombination activating genes, RAG 1 and RAG 2, are on chromosome 11p in humans and chromosome 2p in mice

Marjorie A. Oettinger, Ben Stanger, David G. Schatz, Thomas M Glaser, Kathy Call, David Housman, David Baltimore

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The recombination activating genes RAG-1 and RAG-2 are adjacent genes that act synergistically to activate variable-diversity-joining (V(D)J) recombination. Southern analysis of hybrid cell lines derived from patients with the Wilms tumor-aniridia-genitourinary defects-mental retardation (WAGR) syndrome and from mutagenized cell hybrids selected for deletions in chromosome 11 has allowed us to map the chromosomal location of the human RAG locus. The RAG locus defines a new interval of human chromosome 11p, but is not associated with any genetically mapped human disease. Guided by the chromosomal localization of the human recombination activating genes, we have also mapped the location of the mouse Rag locus.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalImmunogenetics
Volume35
Issue number2
DOIs
StatePublished - 2004
Externally publishedYes

Fingerprint

RAG-1 Genes
Chromosomes, Human, Pair 2
Human Chromosomes
Hybrid Cells
Genetic Recombination
WAGR Syndrome
Aniridia
Chromosomes, Human, Pair 11
Wilms Tumor
Intellectual Disability
Genes
Cell Line

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

The recombination activating genes, RAG 1 and RAG 2, are on chromosome 11p in humans and chromosome 2p in mice. / Oettinger, Marjorie A.; Stanger, Ben; Schatz, David G.; Glaser, Thomas M; Call, Kathy; Housman, David; Baltimore, David.

In: Immunogenetics, Vol. 35, No. 2, 2004, p. 97-101.

Research output: Contribution to journalArticle

Oettinger, MA, Stanger, B, Schatz, DG, Glaser, TM, Call, K, Housman, D & Baltimore, D 2004, 'The recombination activating genes, RAG 1 and RAG 2, are on chromosome 11p in humans and chromosome 2p in mice', Immunogenetics, vol. 35, no. 2, pp. 97-101. https://doi.org/10.1007/BF00189518
Oettinger, Marjorie A. ; Stanger, Ben ; Schatz, David G. ; Glaser, Thomas M ; Call, Kathy ; Housman, David ; Baltimore, David. / The recombination activating genes, RAG 1 and RAG 2, are on chromosome 11p in humans and chromosome 2p in mice. In: Immunogenetics. 2004 ; Vol. 35, No. 2. pp. 97-101.
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