The raas in heart failure: An update on clinical trials and opportunities for therapy

C. Tissa Kappagoda; Ezra A Amsterdam

doi:10.1007/978-1-4939-0268-2_12

The raas in heart failure: An update on clinical trials and opportunities for therapy

C. Tissa Kappagoda, Ezra A Amsterdam

Cardiovascular Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Heart failure continues to be a significant health problem worldwide. Despite significant progress in our understanding of the pathophysiology of the condition, its medical management remains a challenge, with a significant 5-year mortality. At the present time, treatment of heart failure has centered on the idea that its clinical manifestations are associated with a derangement of the renin-angiotensin-aldosterone system (RAAS) leading eventually to retention of salt and water. However, the RAAS is no longer viewed as a single endocrine system operating through blood-borne humoral agents but as a more complex system involving a variety of cell types which influence the functions of the cardiovascular system in health and disease. The latter effects, particularly those involving the actions of nitric oxide and endothelial cell function, may open new options for therapy in the future.

Original language	English (US)
Title of host publication	Aging and Heart Failure: Mechanisms and Management
Publisher	Springer New York
Pages	165-182
Number of pages	18
ISBN (Electronic)	9781493902682
ISBN (Print)	9781493902675
DOIs	https://doi.org/10.1007/978-1-4939-0268-2_12
State	Published - Jan 1 2014

ASJC Scopus subject areas

Medicine (miscellaneous)

Access to Document

10.1007/978-1-4939-0268-2_12

Fingerprint Dive into the research topics of 'The raas in heart failure: An update on clinical trials and opportunities for therapy'. Together they form a unique fingerprint.

Cite this

@inbook{2cb3394370584023b783764d8fd292cb,

title = "The raas in heart failure: An update on clinical trials and opportunities for therapy",

abstract = "Heart failure continues to be a significant health problem worldwide. Despite significant progress in our understanding of the pathophysiology of the condition, its medical management remains a challenge, with a significant 5-year mortality. At the present time, treatment of heart failure has centered on the idea that its clinical manifestations are associated with a derangement of the renin-angiotensin-aldosterone system (RAAS) leading eventually to retention of salt and water. However, the RAAS is no longer viewed as a single endocrine system operating through blood-borne humoral agents but as a more complex system involving a variety of cell types which influence the functions of the cardiovascular system in health and disease. The latter effects, particularly those involving the actions of nitric oxide and endothelial cell function, may open new options for therapy in the future.",

author = "Kappagoda, {C. Tissa} and Amsterdam, {Ezra A}",

year = "2014",

month = jan,

day = "1",

doi = "10.1007/978-1-4939-0268-2_12",

language = "English (US)",

isbn = "9781493902675",

pages = "165--182",

booktitle = "Aging and Heart Failure: Mechanisms and Management",

publisher = "Springer New York",

}

TY - CHAP

T1 - The raas in heart failure

T2 - An update on clinical trials and opportunities for therapy

AU - Kappagoda, C. Tissa

AU - Amsterdam, Ezra A

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Heart failure continues to be a significant health problem worldwide. Despite significant progress in our understanding of the pathophysiology of the condition, its medical management remains a challenge, with a significant 5-year mortality. At the present time, treatment of heart failure has centered on the idea that its clinical manifestations are associated with a derangement of the renin-angiotensin-aldosterone system (RAAS) leading eventually to retention of salt and water. However, the RAAS is no longer viewed as a single endocrine system operating through blood-borne humoral agents but as a more complex system involving a variety of cell types which influence the functions of the cardiovascular system in health and disease. The latter effects, particularly those involving the actions of nitric oxide and endothelial cell function, may open new options for therapy in the future.

AB - Heart failure continues to be a significant health problem worldwide. Despite significant progress in our understanding of the pathophysiology of the condition, its medical management remains a challenge, with a significant 5-year mortality. At the present time, treatment of heart failure has centered on the idea that its clinical manifestations are associated with a derangement of the renin-angiotensin-aldosterone system (RAAS) leading eventually to retention of salt and water. However, the RAAS is no longer viewed as a single endocrine system operating through blood-borne humoral agents but as a more complex system involving a variety of cell types which influence the functions of the cardiovascular system in health and disease. The latter effects, particularly those involving the actions of nitric oxide and endothelial cell function, may open new options for therapy in the future.

UR - http://www.scopus.com/inward/record.url?scp=84960413257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960413257&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-0268-2_12

DO - 10.1007/978-1-4939-0268-2_12

M3 - Chapter

AN - SCOPUS:84960413257

SN - 9781493902675

SP - 165

EP - 182

BT - Aging and Heart Failure: Mechanisms and Management

PB - Springer New York

ER -