Abstract
Heart failure continues to be a significant health problem worldwide. Despite significant progress in our understanding of the pathophysiology of the condition, its medical management remains a challenge, with a significant 5-year mortality. At the present time, treatment of heart failure has centered on the idea that its clinical manifestations are associated with a derangement of the renin-angiotensin-aldosterone system (RAAS) leading eventually to retention of salt and water. However, the RAAS is no longer viewed as a single endocrine system operating through blood-borne humoral agents but as a more complex system involving a variety of cell types which influence the functions of the cardiovascular system in health and disease. The latter effects, particularly those involving the actions of nitric oxide and endothelial cell function, may open new options for therapy in the future.
| Original language | English (US) |
|---|---|
| Title of host publication | Aging and Heart Failure: Mechanisms and Management |
| Publisher | Springer New York |
| Pages | 165-182 |
| Number of pages | 18 |
| ISBN (Electronic) | 9781493902682 |
| ISBN (Print) | 9781493902675 |
| DOIs | |
| State | Published - Jan 1 2014 |
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ASJC Scopus subject areas
- Medicine (miscellaneous)
Cite this
The raas in heart failure : An update on clinical trials and opportunities for therapy. / Kappagoda, C. Tissa; Amsterdam, Ezra A.
Aging and Heart Failure: Mechanisms and Management. Springer New York, 2014. p. 165-182.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - The raas in heart failure
T2 - An update on clinical trials and opportunities for therapy
AU - Kappagoda, C. Tissa
AU - Amsterdam, Ezra A
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Heart failure continues to be a significant health problem worldwide. Despite significant progress in our understanding of the pathophysiology of the condition, its medical management remains a challenge, with a significant 5-year mortality. At the present time, treatment of heart failure has centered on the idea that its clinical manifestations are associated with a derangement of the renin-angiotensin-aldosterone system (RAAS) leading eventually to retention of salt and water. However, the RAAS is no longer viewed as a single endocrine system operating through blood-borne humoral agents but as a more complex system involving a variety of cell types which influence the functions of the cardiovascular system in health and disease. The latter effects, particularly those involving the actions of nitric oxide and endothelial cell function, may open new options for therapy in the future.
AB - Heart failure continues to be a significant health problem worldwide. Despite significant progress in our understanding of the pathophysiology of the condition, its medical management remains a challenge, with a significant 5-year mortality. At the present time, treatment of heart failure has centered on the idea that its clinical manifestations are associated with a derangement of the renin-angiotensin-aldosterone system (RAAS) leading eventually to retention of salt and water. However, the RAAS is no longer viewed as a single endocrine system operating through blood-borne humoral agents but as a more complex system involving a variety of cell types which influence the functions of the cardiovascular system in health and disease. The latter effects, particularly those involving the actions of nitric oxide and endothelial cell function, may open new options for therapy in the future.
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UR - http://www.scopus.com/inward/citedby.url?scp=84960413257&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-0268-2_12
DO - 10.1007/978-1-4939-0268-2_12
M3 - Chapter
AN - SCOPUS:84960413257
SN - 9781493902675
SP - 165
EP - 182
BT - Aging and Heart Failure: Mechanisms and Management
PB - Springer New York
ER -