The Pyromaniac Inside You: Salmonella Metabolism in the Host Gut

Fabian Rivera-Chávez, Andreas J Baumler

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

A metabolically diverse microbial community occupies all available nutrient-niches in the lumen of the mammalian intestine, making it difficult for pathogens to establish themselves in this highly competitive environment. Salmonella serovars sidestep the competition by using their virulence factors to coerce the host into creating a novel nutrient-niche. Inflammation-derived nutrients available in this new niche support a bloom of Salmonella serovars, thereby ensuring transmission of the pathogen to the next susceptible host by the fecal-oral route. Here we review the anaerobic food chain that characterizes resident gut-associated microbial communities along with the winning metabolic strategy Salmonella serovars use to edge out competing microbes in the inflamed intestine. ©

Original languageEnglish (US)
Pages (from-to)31-48
Number of pages18
JournalAnnual Review of Microbiology
Volume69
Issue number1
DOIs
StatePublished - Oct 15 2015

Keywords

  • Anaerobic respiration
  • Diarrhea
  • Gastroenteritis
  • Gastrointestinal pathogens
  • Gut-associated microbial communities

ASJC Scopus subject areas

  • Microbiology

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