The pulmonary circulation in neonatal respiratory failure

Research output: Contribution to journalReview articlepeer-review

52 Scopus citations


The pulmonary circulation rapidly adapts at birth to establish lungs as the site of gas exchange. Abnormal transition at birth and/or parenchymal lung disease can result in neonatal hypoxemic respiratory failure. This article reviews the functional changes in pulmonary hemodynamics and structural changes in pulmonary vasculature secondary to (1) normal and abnormal transition at birth, and (2) diseases associated with neonatal hypoxemic respiratory failure. Various management strategies to correct respiratory failure are also discussed.

Original languageEnglish (US)
Pages (from-to)655-683
Number of pages29
JournalClinics in Perinatology
Issue number3
StatePublished - Sep 1 2012
Externally publishedYes


  • Lungs
  • Neonates
  • Pulmonary circulation
  • Respiratory failure

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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