Abstract
Objective: Recently developed research criteria have made it possible to identify adolescents at imminent risk for psychosis. However, the array of symptomatology in these patients is broad and has not yet been systematically characterized using established diagnostic and assessment tools. Method: The authors characterized 24 adolescent research participants at the UCLA Center for the Assessment and Prevention of Prodromal States (CAPPS) using structured interviews for the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, (DSM-IV), the Child Behavior Checklist (CBCL), and information regarding psychiatric treatment histories. Two composite cases are also presented. Results: The most common DSM-IV diagnosis at study entry was major depression, followed by anxiety disorder not otherwise specified (NOS), and social phobia. Most participants met criteria for at least one subthreshold condition, including obsessive-compulsive disorder (OCD), psychosis, mania or hypomania, and generalized anxiety. CBCL data revealed high rates of affective disturbance and broad-ranging symptomatology, as did participants' diagnostic and treatment histories. Conclusions: Consistent with retrospective studies of patients with first-episode psychosis, findings revealed frequent mood and anxiety disturbance during the prodromal phase of illness. The DSM-IV does not offer a clear framework for describing the widespread subthreshold symptomatology that characterizes putatively prodromal patients. The authors consider whether the psychosis prodrome merits designation as a recognized clinical entity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 434-451 |
| Number of pages | 18 |
| Journal | Journal of Child and Adolescent Psychopharmacology |
| Volume | 15 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2005 |
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ASJC Scopus subject areas
- Pharmacology (medical)
- Psychiatry and Mental health
- Pediatrics, Perinatology, and Child Health
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
The psychosis prodrome in adolescent patients viewed through the lens of DSM-IV. / Meyer, Stephanie E.; Bearden, Carrie E.; Lux, Sabrina R.; Gordon, Jamie L.; Johnson, Jennifer K.; O'Brien, Mary P.; Niendam, Tara A; Loewy, Rachel L.; Ventura, Joseph; Cannon, Tyrone D.
In: Journal of Child and Adolescent Psychopharmacology, Vol. 15, No. 3, 06.2005, p. 434-451.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The psychosis prodrome in adolescent patients viewed through the lens of DSM-IV
AU - Meyer, Stephanie E.
AU - Bearden, Carrie E.
AU - Lux, Sabrina R.
AU - Gordon, Jamie L.
AU - Johnson, Jennifer K.
AU - O'Brien, Mary P.
AU - Niendam, Tara A
AU - Loewy, Rachel L.
AU - Ventura, Joseph
AU - Cannon, Tyrone D.
PY - 2005/6
Y1 - 2005/6
N2 - Objective: Recently developed research criteria have made it possible to identify adolescents at imminent risk for psychosis. However, the array of symptomatology in these patients is broad and has not yet been systematically characterized using established diagnostic and assessment tools. Method: The authors characterized 24 adolescent research participants at the UCLA Center for the Assessment and Prevention of Prodromal States (CAPPS) using structured interviews for the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, (DSM-IV), the Child Behavior Checklist (CBCL), and information regarding psychiatric treatment histories. Two composite cases are also presented. Results: The most common DSM-IV diagnosis at study entry was major depression, followed by anxiety disorder not otherwise specified (NOS), and social phobia. Most participants met criteria for at least one subthreshold condition, including obsessive-compulsive disorder (OCD), psychosis, mania or hypomania, and generalized anxiety. CBCL data revealed high rates of affective disturbance and broad-ranging symptomatology, as did participants' diagnostic and treatment histories. Conclusions: Consistent with retrospective studies of patients with first-episode psychosis, findings revealed frequent mood and anxiety disturbance during the prodromal phase of illness. The DSM-IV does not offer a clear framework for describing the widespread subthreshold symptomatology that characterizes putatively prodromal patients. The authors consider whether the psychosis prodrome merits designation as a recognized clinical entity.
AB - Objective: Recently developed research criteria have made it possible to identify adolescents at imminent risk for psychosis. However, the array of symptomatology in these patients is broad and has not yet been systematically characterized using established diagnostic and assessment tools. Method: The authors characterized 24 adolescent research participants at the UCLA Center for the Assessment and Prevention of Prodromal States (CAPPS) using structured interviews for the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, (DSM-IV), the Child Behavior Checklist (CBCL), and information regarding psychiatric treatment histories. Two composite cases are also presented. Results: The most common DSM-IV diagnosis at study entry was major depression, followed by anxiety disorder not otherwise specified (NOS), and social phobia. Most participants met criteria for at least one subthreshold condition, including obsessive-compulsive disorder (OCD), psychosis, mania or hypomania, and generalized anxiety. CBCL data revealed high rates of affective disturbance and broad-ranging symptomatology, as did participants' diagnostic and treatment histories. Conclusions: Consistent with retrospective studies of patients with first-episode psychosis, findings revealed frequent mood and anxiety disturbance during the prodromal phase of illness. The DSM-IV does not offer a clear framework for describing the widespread subthreshold symptomatology that characterizes putatively prodromal patients. The authors consider whether the psychosis prodrome merits designation as a recognized clinical entity.
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UR - http://www.scopus.com/inward/citedby.url?scp=21444453457&partnerID=8YFLogxK
U2 - 10.1089/cap.2005.15.434
DO - 10.1089/cap.2005.15.434
M3 - Article
VL - 15
SP - 434
EP - 451
JO - Journal of Child and Adolescent Psychopharmacology
JF - Journal of Child and Adolescent Psychopharmacology
SN - 1044-5463
IS - 3
ER -