The protein tyrosine phosphatase SHP-2 is expressed in glial and neuronal progenitor cells, postmitotic neurons and reactive astrocytes

T. Servidei, P. G. Bhide, Z. Huang, M. A. Moskowitz, G. Harsh, S. A. Reeves

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

In this study we examined the distribution and developmental profile of the src homology 2 (SH2) domain-containing protein tyrosine phosphatase SHP- 2 in the mouse brain. We found that SHP-2 is present in both mitotically active and postmitotic cells in the forebrains of embryonic day 12 (E12) mice. In a developmental study extending from embryonic day 12 to adulthood, Western blotting analysis demonstrated equivalent levels of SHP-2 protein at all of the ages examined. Expression of SHP-2 paralleled the level of enzymatic activity at the different developmental periods. In the adult brain SHP-2 was restricted to diverse classes of neurons, while the majority of glial cells did not express detectable levels of protein. However, reactive astrocytes in response to an ischemic brain injury showed SHP-2 immunolabelling. Our data suggest that SHP-2 may play a role in pathways of neuronal and glial progenitor cells, in a broad spectrum of neuronal responses in the adult brain and in the gliotic response to the injury.

Original languageEnglish (US)
Pages (from-to)529-543
Number of pages15
JournalNeuroscience
Volume82
Issue number2
DOIs
StatePublished - Oct 17 1997
Externally publishedYes

Keywords

  • Astrocytic reaction
  • Gliogenesis
  • Growth factors
  • Ischemia
  • Neurogenesis
  • SHP-2

ASJC Scopus subject areas

  • Neuroscience(all)

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