The Protective Action Encoding of Serotonin Transients in the Human Brain

Rosalyn J. Moran, Kenneth T. Kishida, Terry Lohrenz, Ignacio Saez, Adrian W. Laxton, Mark R. Witcher, Stephen B. Tatter, Thomas L. Ellis, Paul Em Phillips, Peter Dayan, P. Read Montague

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The role of serotonin in human brain function remains elusive due, at least in part, to our inability to measure rapidly the local concentration of this neurotransmitter. We used fast-scan cyclic voltammetry to infer serotonergic signaling from the striatum of 14 brains of human patients with Parkinson's disease. Here we report these novel measurements and show that they correlate with outcomes and decisions in a sequential investment game. We find that serotonergic concentrations transiently increase as a whole following negative reward prediction errors, while reversing when counterfactual losses predominate. This provides initial evidence that the serotonergic system acts as an opponent to dopamine signaling, as anticipated by theoretical models. Serotonin transients on one trial were also associated with actions on the next trial in a manner that correlated with decreased exposure to poor outcomes. Thus, the fluctuations observed for serotonin appear to correlate with the inhibition of over-reactions and promote persistence of ongoing strategies in the face of short-term environmental changes. Together these findings elucidate a role for serotonin in the striatum, suggesting it encodes a protective action strategy that mitigates risk and modulates choice selection particularly following negative environmental events.

Original languageEnglish (US)
Pages (from-to)1425-1435
Number of pages11
JournalNeuropsychopharmacology
Volume43
Issue number6
DOIs
StatePublished - May 1 2018
Externally publishedYes

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Serotonin
Brain
Reward
Neurotransmitter Agents
Parkinson Disease
Dopamine
Theoretical Models

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Moran, R. J., Kishida, K. T., Lohrenz, T., Saez, I., Laxton, A. W., Witcher, M. R., ... Montague, P. R. (2018). The Protective Action Encoding of Serotonin Transients in the Human Brain. Neuropsychopharmacology, 43(6), 1425-1435. https://doi.org/10.1038/npp.2017.304

The Protective Action Encoding of Serotonin Transients in the Human Brain. / Moran, Rosalyn J.; Kishida, Kenneth T.; Lohrenz, Terry; Saez, Ignacio; Laxton, Adrian W.; Witcher, Mark R.; Tatter, Stephen B.; Ellis, Thomas L.; Phillips, Paul Em; Dayan, Peter; Montague, P. Read.

In: Neuropsychopharmacology, Vol. 43, No. 6, 01.05.2018, p. 1425-1435.

Research output: Contribution to journalArticle

Moran, RJ, Kishida, KT, Lohrenz, T, Saez, I, Laxton, AW, Witcher, MR, Tatter, SB, Ellis, TL, Phillips, PE, Dayan, P & Montague, PR 2018, 'The Protective Action Encoding of Serotonin Transients in the Human Brain', Neuropsychopharmacology, vol. 43, no. 6, pp. 1425-1435. https://doi.org/10.1038/npp.2017.304
Moran RJ, Kishida KT, Lohrenz T, Saez I, Laxton AW, Witcher MR et al. The Protective Action Encoding of Serotonin Transients in the Human Brain. Neuropsychopharmacology. 2018 May 1;43(6):1425-1435. https://doi.org/10.1038/npp.2017.304
Moran, Rosalyn J. ; Kishida, Kenneth T. ; Lohrenz, Terry ; Saez, Ignacio ; Laxton, Adrian W. ; Witcher, Mark R. ; Tatter, Stephen B. ; Ellis, Thomas L. ; Phillips, Paul Em ; Dayan, Peter ; Montague, P. Read. / The Protective Action Encoding of Serotonin Transients in the Human Brain. In: Neuropsychopharmacology. 2018 ; Vol. 43, No. 6. pp. 1425-1435.
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