The prospects for designer single-stranded RNA-binding proteins

Joel P. MacKay, Josep Font, David Segal

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Spectacular progress has been made in the design of proteins that recognize double-stranded DNA with a chosen specificity, to the point that designer DNA-binding proteins can be ordered commercially. This success raises the question of whether it will be possible to engineer libraries of proteins that can recognize RNA with tailored specificity. Given the recent explosion in the number and diversity of RNA species demonstrated to play roles in biology, designer RNA-binding proteins are set to become valuable tools, both in the research laboratory and potentially in the clinic. Here we discuss the prospects for the realization of this idea.

Original languageEnglish (US)
Pages (from-to)256-261
Number of pages6
JournalNature Structural and Molecular Biology
Issue number3
StatePublished - Mar 2011

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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