The promise of CaMKII inhibition for heart disease: Preventing heart failure and arrhythmias

B. Daan Westenbrink, Andrew G. Edwards, Andrew D. McCulloch, Joan Heller Brown

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Introduction: Calcium-calmodulin-dependent protein kinase II (CaMKII) has emerged as a central mediator of cardiac stress responses which may serve several critical roles in the regulation of cardiac rhythm, cardiac contractility and growth. Sustained and excessive activation of CaMKII during cardiac disease has, however, been linked to arrhythmias, and maladaptive cardiac remodeling, eventually leading to heart failure (HF) and sudden cardiac death. Areas covered: In the current review, the authors describe the unique structural and biochemical properties of CaMKII and focus on its physiological effects in cardiomyocytes. Furthermore, they provide evidence for a role of CaMKII in cardiac pathologies, including arrhythmogenesis, myocardial ischemia and HF development. The authors conclude by discussing the potential for CaMKII as a target for inhibition in heart disease. Expert opinion: CaMKII provides a promising nodal point for intervention that may allow simultaneous prevention of HF progression and development of arrhythmias. For future studies and drug development there is a strong rationale for the development of more specific CaMKII inhibitors. In addition, an improved understanding of the differential roles of CaMKII subtypes is required.

Original languageEnglish (US)
Pages (from-to)889-903
Number of pages15
JournalExpert Opinion on Therapeutic Targets
Volume17
Issue number8
DOIs
StatePublished - Aug 1 2013
Externally publishedYes

Keywords

  • Arrhythmia
  • CaMKII
  • Heart failure
  • Ischemia
  • Mitochondria

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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