The prognostic value of cerebrospinal fluid characteristics in dogs without deep pain perception due to thoracolumbar disc herniation

Y. Chamisha, I. Aroch, S. Kuzi, I. Srugo, T. Bdolah-Abram, O. Chai, Mary M Christopher, Y. Merbl, K. Rothwell, M. H. Shamir

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Providing a pre-operative prognosis for dogs presented with absent deep pain perception (DPP) is extremely challenging, as the overall recovery rates widely vary. This study assesses the possible correlation between the severity of spinal cord injury and CSF cytology in 31 paraplegic dogs presented with absent DPP due to acute thoracolumbar intervertebral disc herniation (TL-IVDH). All dogs underwent surgical decompression immediately following diagnosis. CSF TNCC, macrophage percentage and macrophage to monocyte (MΦ:M) ratio were significantly higher in dogs that failed to regain DPP within 10 days post-operatively and in dogs that failed to regain ambulation at the end of the study period (P < 0.05). MΦ:M of 0.73 and higher corresponded to a sensitivity of 54% and specificity of 100% for prediction of a negative long-term outcome. CSF TNCC, macrophage percentage and MΦ:M ratio effectively predicted regaining DPP and the long-term outcome in dogs that lost DPP due to acute TL-IVDH.

Original languageEnglish (US)
Pages (from-to)189-196
Number of pages8
JournalResearch in Veterinary Science
Volume100
DOIs
StatePublished - Jun 1 2015

Fingerprint

Pain Perception
cerebrospinal fluid
Cerebrospinal Fluid
pain
Dogs
macrophages
Macrophages
dogs
monocytes
Monocytes
intervertebral disks
Intervertebral Disc
Surgical Decompression
Spinal Cord Injuries
spinal cord
cell biology
prognosis
Walking
Cell Biology
Sensitivity and Specificity

Keywords

  • CSF
  • Deep pain perception
  • Dog
  • Intervertebral disc herniation
  • Prognosis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

The prognostic value of cerebrospinal fluid characteristics in dogs without deep pain perception due to thoracolumbar disc herniation. / Chamisha, Y.; Aroch, I.; Kuzi, S.; Srugo, I.; Bdolah-Abram, T.; Chai, O.; Christopher, Mary M; Merbl, Y.; Rothwell, K.; Shamir, M. H.

In: Research in Veterinary Science, Vol. 100, 01.06.2015, p. 189-196.

Research output: Contribution to journalArticle

Chamisha, Y. ; Aroch, I. ; Kuzi, S. ; Srugo, I. ; Bdolah-Abram, T. ; Chai, O. ; Christopher, Mary M ; Merbl, Y. ; Rothwell, K. ; Shamir, M. H. / The prognostic value of cerebrospinal fluid characteristics in dogs without deep pain perception due to thoracolumbar disc herniation. In: Research in Veterinary Science. 2015 ; Vol. 100. pp. 189-196.
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