The prognostic significance of S-Phase analysis in stage Ta/T1 bladder cancer. A Southwest Oncology Group study

Ralph W deVere White, Arline D. Deitch, Siamak Daneshmand, Brent Blumenstein, Bruce A. Lowe, Arthur I. Sagalowsky, Joseph A. Smith, Paul F. Schellhammer, Thomas H. Stanisic, H. Barton Grossman, Edward Messing, John D. Crissman, E. David Crawford

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Abstract

Objectives: An intergroup study (SWOG 8795) comparing two forms of adjunctive therapy (immuno and chemo), bacillus Calmette-Guerin (BCG) and mitomycin C (MMC), furnished preregistration index tumors for 244 patients with superficial, papillary stage Ta/T1 TCC. These were examined by flow cytometry to learn whether DNA ploidy or proliferation (low vs high S-phase fraction (SPF) helped to predict disease recurrence or progression. Methods: Cell cycle analysis using commercially available (Multicycle) programs was performed on 249 Ta/T1 bladder cancers. Tumor grade, available for 223 cases, was assigned by a single study pathologist. The SWOG statistical office reviewed follow-up information and other data and performed statistical analysis. Results: Disease recurrence occurred in half the cases studied. The most parsimonious model predictive of recurrence included only treatment arm and tumor grade, with the MMC arm and tumor grade greater than I indicating worse prognosis (p = 0.014). Neither ploidy nor SPF predicted recurrence-free survival or contributed prognostic information that was additive to tumor grade. Within 5 years of follow-up, disease progression or death from bladder cancer occurred for 29/223 (13%) of patients. The most parsimonious model for progression-free survival included only grade greater than I (p < 0.001) and high SPF (p = 0.029) (relative risk: tumor grade, 4.3, high SPF, 1.9). Conclusions: Knowledge of tumor proliferation (low versus high SPF) contributes prognostic information about tumor progression that is additive to tumor grade. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish (US)
Pages (from-to)595-600
Number of pages6
JournalEuropean Urology
Volume37
Issue number5
StatePublished - 2000

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S Phase
Urinary Bladder Neoplasms
Neoplasms
Recurrence
Ploidies
Mitomycin
Statistical Data Interpretation
Mycobacterium bovis
Disease-Free Survival
Disease Progression
Cell Cycle
Flow Cytometry
Survival
DNA
Therapeutics

Keywords

  • Bladder neoplasm
  • Cell cycle
  • Flow cytometry
  • Statistical models

ASJC Scopus subject areas

  • Urology

Cite this

deVere White, R. W., Deitch, A. D., Daneshmand, S., Blumenstein, B., Lowe, B. A., Sagalowsky, A. I., ... Crawford, E. D. (2000). The prognostic significance of S-Phase analysis in stage Ta/T1 bladder cancer. A Southwest Oncology Group study. European Urology, 37(5), 595-600.

The prognostic significance of S-Phase analysis in stage Ta/T1 bladder cancer. A Southwest Oncology Group study. / deVere White, Ralph W; Deitch, Arline D.; Daneshmand, Siamak; Blumenstein, Brent; Lowe, Bruce A.; Sagalowsky, Arthur I.; Smith, Joseph A.; Schellhammer, Paul F.; Stanisic, Thomas H.; Grossman, H. Barton; Messing, Edward; Crissman, John D.; Crawford, E. David.

In: European Urology, Vol. 37, No. 5, 2000, p. 595-600.

Research output: Contribution to journalArticle

deVere White, RW, Deitch, AD, Daneshmand, S, Blumenstein, B, Lowe, BA, Sagalowsky, AI, Smith, JA, Schellhammer, PF, Stanisic, TH, Grossman, HB, Messing, E, Crissman, JD & Crawford, ED 2000, 'The prognostic significance of S-Phase analysis in stage Ta/T1 bladder cancer. A Southwest Oncology Group study', European Urology, vol. 37, no. 5, pp. 595-600.
deVere White RW, Deitch AD, Daneshmand S, Blumenstein B, Lowe BA, Sagalowsky AI et al. The prognostic significance of S-Phase analysis in stage Ta/T1 bladder cancer. A Southwest Oncology Group study. European Urology. 2000;37(5):595-600.
deVere White, Ralph W ; Deitch, Arline D. ; Daneshmand, Siamak ; Blumenstein, Brent ; Lowe, Bruce A. ; Sagalowsky, Arthur I. ; Smith, Joseph A. ; Schellhammer, Paul F. ; Stanisic, Thomas H. ; Grossman, H. Barton ; Messing, Edward ; Crissman, John D. ; Crawford, E. David. / The prognostic significance of S-Phase analysis in stage Ta/T1 bladder cancer. A Southwest Oncology Group study. In: European Urology. 2000 ; Vol. 37, No. 5. pp. 595-600.
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abstract = "Objectives: An intergroup study (SWOG 8795) comparing two forms of adjunctive therapy (immuno and chemo), bacillus Calmette-Guerin (BCG) and mitomycin C (MMC), furnished preregistration index tumors for 244 patients with superficial, papillary stage Ta/T1 TCC. These were examined by flow cytometry to learn whether DNA ploidy or proliferation (low vs high S-phase fraction (SPF) helped to predict disease recurrence or progression. Methods: Cell cycle analysis using commercially available (Multicycle) programs was performed on 249 Ta/T1 bladder cancers. Tumor grade, available for 223 cases, was assigned by a single study pathologist. The SWOG statistical office reviewed follow-up information and other data and performed statistical analysis. Results: Disease recurrence occurred in half the cases studied. The most parsimonious model predictive of recurrence included only treatment arm and tumor grade, with the MMC arm and tumor grade greater than I indicating worse prognosis (p = 0.014). Neither ploidy nor SPF predicted recurrence-free survival or contributed prognostic information that was additive to tumor grade. Within 5 years of follow-up, disease progression or death from bladder cancer occurred for 29/223 (13{\%}) of patients. The most parsimonious model for progression-free survival included only grade greater than I (p < 0.001) and high SPF (p = 0.029) (relative risk: tumor grade, 4.3, high SPF, 1.9). Conclusions: Knowledge of tumor proliferation (low versus high SPF) contributes prognostic information about tumor progression that is additive to tumor grade. Copyright (C) 2000 S. Karger AG, Basel.",
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T1 - The prognostic significance of S-Phase analysis in stage Ta/T1 bladder cancer. A Southwest Oncology Group study

AU - deVere White, Ralph W

AU - Deitch, Arline D.

AU - Daneshmand, Siamak

AU - Blumenstein, Brent

AU - Lowe, Bruce A.

AU - Sagalowsky, Arthur I.

AU - Smith, Joseph A.

AU - Schellhammer, Paul F.

AU - Stanisic, Thomas H.

AU - Grossman, H. Barton

AU - Messing, Edward

AU - Crissman, John D.

AU - Crawford, E. David

PY - 2000

Y1 - 2000

N2 - Objectives: An intergroup study (SWOG 8795) comparing two forms of adjunctive therapy (immuno and chemo), bacillus Calmette-Guerin (BCG) and mitomycin C (MMC), furnished preregistration index tumors for 244 patients with superficial, papillary stage Ta/T1 TCC. These were examined by flow cytometry to learn whether DNA ploidy or proliferation (low vs high S-phase fraction (SPF) helped to predict disease recurrence or progression. Methods: Cell cycle analysis using commercially available (Multicycle) programs was performed on 249 Ta/T1 bladder cancers. Tumor grade, available for 223 cases, was assigned by a single study pathologist. The SWOG statistical office reviewed follow-up information and other data and performed statistical analysis. Results: Disease recurrence occurred in half the cases studied. The most parsimonious model predictive of recurrence included only treatment arm and tumor grade, with the MMC arm and tumor grade greater than I indicating worse prognosis (p = 0.014). Neither ploidy nor SPF predicted recurrence-free survival or contributed prognostic information that was additive to tumor grade. Within 5 years of follow-up, disease progression or death from bladder cancer occurred for 29/223 (13%) of patients. The most parsimonious model for progression-free survival included only grade greater than I (p < 0.001) and high SPF (p = 0.029) (relative risk: tumor grade, 4.3, high SPF, 1.9). Conclusions: Knowledge of tumor proliferation (low versus high SPF) contributes prognostic information about tumor progression that is additive to tumor grade. Copyright (C) 2000 S. Karger AG, Basel.

AB - Objectives: An intergroup study (SWOG 8795) comparing two forms of adjunctive therapy (immuno and chemo), bacillus Calmette-Guerin (BCG) and mitomycin C (MMC), furnished preregistration index tumors for 244 patients with superficial, papillary stage Ta/T1 TCC. These were examined by flow cytometry to learn whether DNA ploidy or proliferation (low vs high S-phase fraction (SPF) helped to predict disease recurrence or progression. Methods: Cell cycle analysis using commercially available (Multicycle) programs was performed on 249 Ta/T1 bladder cancers. Tumor grade, available for 223 cases, was assigned by a single study pathologist. The SWOG statistical office reviewed follow-up information and other data and performed statistical analysis. Results: Disease recurrence occurred in half the cases studied. The most parsimonious model predictive of recurrence included only treatment arm and tumor grade, with the MMC arm and tumor grade greater than I indicating worse prognosis (p = 0.014). Neither ploidy nor SPF predicted recurrence-free survival or contributed prognostic information that was additive to tumor grade. Within 5 years of follow-up, disease progression or death from bladder cancer occurred for 29/223 (13%) of patients. The most parsimonious model for progression-free survival included only grade greater than I (p < 0.001) and high SPF (p = 0.029) (relative risk: tumor grade, 4.3, high SPF, 1.9). Conclusions: Knowledge of tumor proliferation (low versus high SPF) contributes prognostic information about tumor progression that is additive to tumor grade. Copyright (C) 2000 S. Karger AG, Basel.

KW - Bladder neoplasm

KW - Cell cycle

KW - Flow cytometry

KW - Statistical models

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M3 - Article

VL - 37

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EP - 600

JO - European Urology

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