Abstract
An antibody has been labelled with generator produced yttrium-90 (90Y) via a chelating group (DTPA) covalently attached to the protein. An average yield for protein labelling of 76% was obtained. The blood clearance of iodinated and 90Y labelled antibody is similar in rats and mice. However, in contrast to iodine, the yttrium label accumulates in the liver after release from the protein.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 803-806 |
| Number of pages | 4 |
| Journal | The International Journal Of Applied Radiation And Isotopes |
| Volume | 36 |
| Issue number | 10 |
| DOIs | |
| State | Published - 1985 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Nuclear Energy and Engineering
- Radiology Nuclear Medicine and imaging
- Radiation
Cite this
The production and biological distribution of yttrium-90 labelled antibodies. / Vaughan, Andrew T M; Keeling, A.; Yankuba, S. C S.
In: The International Journal Of Applied Radiation And Isotopes, Vol. 36, No. 10, 1985, p. 803-806.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The production and biological distribution of yttrium-90 labelled antibodies
AU - Vaughan, Andrew T M
AU - Keeling, A.
AU - Yankuba, S. C S
PY - 1985
Y1 - 1985
N2 - An antibody has been labelled with generator produced yttrium-90 (90Y) via a chelating group (DTPA) covalently attached to the protein. An average yield for protein labelling of 76% was obtained. The blood clearance of iodinated and 90Y labelled antibody is similar in rats and mice. However, in contrast to iodine, the yttrium label accumulates in the liver after release from the protein.
AB - An antibody has been labelled with generator produced yttrium-90 (90Y) via a chelating group (DTPA) covalently attached to the protein. An average yield for protein labelling of 76% was obtained. The blood clearance of iodinated and 90Y labelled antibody is similar in rats and mice. However, in contrast to iodine, the yttrium label accumulates in the liver after release from the protein.
UR - http://www.scopus.com/inward/record.url?scp=0022147008&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022147008&partnerID=8YFLogxK
U2 - 10.1016/0020-708X(85)90031-6
DO - 10.1016/0020-708X(85)90031-6
M3 - Article
VL - 36
SP - 803
EP - 806
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
IS - 10
ER -