The production and biological distribution of yttrium-90 labelled antibodies

Andrew T M Vaughan, A. Keeling, S. C S Yankuba

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

An antibody has been labelled with generator produced yttrium-90 (90Y) via a chelating group (DTPA) covalently attached to the protein. An average yield for protein labelling of 76% was obtained. The blood clearance of iodinated and 90Y labelled antibody is similar in rats and mice. However, in contrast to iodine, the yttrium label accumulates in the liver after release from the protein.

Original languageEnglish (US)
Pages (from-to)803-806
Number of pages4
JournalThe International Journal Of Applied Radiation And Isotopes
Volume36
Issue number10
DOIs
StatePublished - 1985
Externally publishedYes

Fingerprint

Yttrium
antibodies
yttrium
Antibodies
proteins
Proteins
Pentetic Acid
clearances
Chelation
Iodine
liver
Liver
Labeling
rats
marking
iodine
blood
mice
Rats
Labels

ASJC Scopus subject areas

  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Radiation

Cite this

The production and biological distribution of yttrium-90 labelled antibodies. / Vaughan, Andrew T M; Keeling, A.; Yankuba, S. C S.

In: The International Journal Of Applied Radiation And Isotopes, Vol. 36, No. 10, 1985, p. 803-806.

Research output: Contribution to journalArticle

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