The production and biological distribution of yttrium-90 labelled antibodies

Andrew T M Vaughan, A. Keeling, S. C S Yankuba

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

An antibody has been labelled with generator produced yttrium-90 (90Y) via a chelating group (DTPA) covalently attached to the protein. An average yield for protein labelling of 76% was obtained. The blood clearance of iodinated and 90Y labelled antibody is similar in rats and mice. However, in contrast to iodine, the yttrium label accumulates in the liver after release from the protein.

Original languageEnglish (US)
Pages (from-to)803-806
Number of pages4
JournalThe International Journal Of Applied Radiation And Isotopes
Volume36
Issue number10
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Radiation

Fingerprint Dive into the research topics of 'The production and biological distribution of yttrium-90 labelled antibodies'. Together they form a unique fingerprint.

  • Cite this