The production and biological distribution of yttrium-90 labelled antibodies

Andrew T M Vaughan; A. Keeling; S. C S Yankuba

doi:10.1016/0020-708X(85)90031-6

The production and biological distribution of yttrium-90 labelled antibodies

Andrew T M Vaughan, A. Keeling, S. C S Yankuba

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37 Scopus citations

Abstract

An antibody has been labelled with generator produced yttrium-90 (⁹⁰Y) via a chelating group (DTPA) covalently attached to the protein. An average yield for protein labelling of 76% was obtained. The blood clearance of iodinated and ⁹⁰Y labelled antibody is similar in rats and mice. However, in contrast to iodine, the yttrium label accumulates in the liver after release from the protein.

Original language	English (US)
Pages (from-to)	803-806
Number of pages	4
Journal	The International Journal Of Applied Radiation And Isotopes
Volume	36
Issue number	10
DOIs	https://doi.org/10.1016/0020-708X(85)90031-6
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Radiation

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10.1016/0020-708X(85)90031-6

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title = "The production and biological distribution of yttrium-90 labelled antibodies",

abstract = "An antibody has been labelled with generator produced yttrium-90 (90Y) via a chelating group (DTPA) covalently attached to the protein. An average yield for protein labelling of 76% was obtained. The blood clearance of iodinated and 90Y labelled antibody is similar in rats and mice. However, in contrast to iodine, the yttrium label accumulates in the liver after release from the protein.",

author = "Vaughan, {Andrew T M} and A. Keeling and Yankuba, {S. C S}",

year = "1985",

doi = "10.1016/0020-708X(85)90031-6",

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AU - Keeling, A.

AU - Yankuba, S. C S

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AB - An antibody has been labelled with generator produced yttrium-90 (90Y) via a chelating group (DTPA) covalently attached to the protein. An average yield for protein labelling of 76% was obtained. The blood clearance of iodinated and 90Y labelled antibody is similar in rats and mice. However, in contrast to iodine, the yttrium label accumulates in the liver after release from the protein.

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The production and biological distribution of yttrium-90 labelled antibodies

Abstract

ASJC Scopus subject areas

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