The preterm infant stomach actively degrades milk proteins with increasing breakdown across digestion time

Veronique Demers-Mathieu, Yunyao Qu, Mark Underwood, David C. Dallas

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: This study investigated the effect of time post-ingestion on gastric digestion and gastric hormones after feeding preterm infants unfortified and fortified human milk. Methods: Human milk and infant gastric samples were collected from 14 preterm (23-32 weeks birth gestational age) mother-infant pairs within 7-98 days postnatal age. Gastric samples were collected one, two and three hours after beginning of feeding. Samples were analysed for pH, proteolysis, general protease activity and the concentrations of pepsin, gastrin and gastrin-releasing peptide (GRP). One-way ANOVA with repeated measures followed by Tukey's multiple comparisons test was used. Results: Gastric pH was significantly decreased after each hour in the preterm infant stomach from one to three hours postprandial. Proteolysis increased significantly from human milk to gastric contents at one, two and three hours postprandial (by 62, 131% and 181%, p < 0.05). General protease activity increased significantly by 58% from human milk to the gastric contents at two hours postprandial. GRP was present in human milk, whereas gastrin was produced in the infant stomach. Conclusion: Although preterm infants may digest human milk proteins to a lesser extent than term infants, we demonstrated that the preterm infant stomach actively degrades milk proteins with increasing breakdown over digestion time.

Original languageEnglish (US)
JournalActa Paediatrica, International Journal of Paediatrics
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Milk Proteins
Premature Infants
Digestion
Stomach
Human Milk
Gastrin-Releasing Peptide
Gastrointestinal Contents
Gastrins
Proteolysis
Peptide Hydrolases
Surrogate Mothers
Pepsin A
Gestational Age
Analysis of Variance
Eating
Parturition
Hormones

Keywords

  • Enzyme
  • Gastric proteolysis
  • Gastrointestinal hormones
  • Pepsin
  • Preterm milk

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

The preterm infant stomach actively degrades milk proteins with increasing breakdown across digestion time. / Demers-Mathieu, Veronique; Qu, Yunyao; Underwood, Mark; Dallas, David C.

In: Acta Paediatrica, International Journal of Paediatrics, 01.01.2018.

Research output: Contribution to journalArticle

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