The present status of vaccination against coccidioidomycosis in man

Research output: Contribution to journalArticle

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Abstract

Pappagianis, D. (School of Medicine, U of California, Davis, CA 95616) and H. B. Levine. The present status of vaccination against coccidioidomycosis in man. Am J Epidemiol 102:30-41, 1975.-Vaccines of killed whole cells of Coccidioides immitis have been injected intramuscularly in 97 human subjects to determine the safety and tolerable dose of vaccine and certain immunologic responses. Seventyeight individuals received the whole killed spherule preparation; 18 received killed mycelial vaccine. The maximum tolerable dose of spherule vaccine was approximately 5 mg. Systemic effects were slight though in two prior coccidioidin reactors a moderate febrile illness and substantial antibody production followed vaccination with killed spherules. The vaccines irregularly induced antibody or delayed hypersensitivity to coccidioidin or spherule antigen. Greater antigenic mass perhaps as a soluble preparation may be needed for consistent immunologic stimulation though the spherule vaccine may be protective despite absence of detectable antibody or sensitivity to coccidioidin.

Original languageEnglish (US)
Pages (from-to)30-41
Number of pages12
JournalAmerican Journal of Epidemiology
Volume102
Issue number1
StatePublished - Jul 1975

Fingerprint

Coccidioidomycosis
Coccidioidin
Vaccination
Vaccines
Inactivated Vaccines
Coccidioides
Antibodies
Delayed Hypersensitivity
Antibody Formation
Immunization
Fever
Medicine
Safety
Antigens

Keywords

  • Coccidioides immitis
  • Coccidioidomycosis vaccine
  • Fungal vaccines

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Epidemiology

Cite this

The present status of vaccination against coccidioidomycosis in man. / Pappagianis, Demosthenes; Levine, H. B.

In: American Journal of Epidemiology, Vol. 102, No. 1, 07.1975, p. 30-41.

Research output: Contribution to journalArticle

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