The preparation of astatotyrosine

Andrew T M Vaughan; J. H. Fremlin

doi:10.1016/0020-708X(77)90043-6

The preparation of astatotyrosine

Andrew T M Vaughan, J. H. Fremlin

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20 Scopus citations

Abstract

The reaction between astatine, an artificially produced halogen, and the l-amino acid tyrosine, has been investigated. Results of kinetic analyses confirm an electrophilic mechanism for astatotyrosine production, similar to that proposed for iodotyrosine. Studies on the stability of the resulting compound are presented with special reference to the potential in vivo uses for the alpha-emitting isotope ²¹¹At, attached to the tyrosine component of biologically active proteins.

Original language	English (US)
Pages (from-to)	595-598
Number of pages	4
Journal	The International Journal Of Applied Radiation And Isotopes
Volume	28
Issue number	6
DOIs	https://doi.org/10.1016/0020-708X(77)90043-6
State	Published - 1977
Externally published	Yes

ASJC Scopus subject areas

Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Radiation

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10.1016/0020-708X(77)90043-6

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title = "The preparation of astatotyrosine",

abstract = "The reaction between astatine, an artificially produced halogen, and the l-amino acid tyrosine, has been investigated. Results of kinetic analyses confirm an electrophilic mechanism for astatotyrosine production, similar to that proposed for iodotyrosine. Studies on the stability of the resulting compound are presented with special reference to the potential in vivo uses for the alpha-emitting isotope 211At, attached to the tyrosine component of biologically active proteins.",

author = "Vaughan, {Andrew T M} and Fremlin, {J. H.}",

year = "1977",

doi = "10.1016/0020-708X(77)90043-6",

language = "English (US)",

volume = "28",

pages = "595--598",

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T1 - The preparation of astatotyrosine

AU - Vaughan, Andrew T M

AU - Fremlin, J. H.

PY - 1977

Y1 - 1977

N2 - The reaction between astatine, an artificially produced halogen, and the l-amino acid tyrosine, has been investigated. Results of kinetic analyses confirm an electrophilic mechanism for astatotyrosine production, similar to that proposed for iodotyrosine. Studies on the stability of the resulting compound are presented with special reference to the potential in vivo uses for the alpha-emitting isotope 211At, attached to the tyrosine component of biologically active proteins.

AB - The reaction between astatine, an artificially produced halogen, and the l-amino acid tyrosine, has been investigated. Results of kinetic analyses confirm an electrophilic mechanism for astatotyrosine production, similar to that proposed for iodotyrosine. Studies on the stability of the resulting compound are presented with special reference to the potential in vivo uses for the alpha-emitting isotope 211At, attached to the tyrosine component of biologically active proteins.

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U2 - 10.1016/0020-708X(77)90043-6

DO - 10.1016/0020-708X(77)90043-6

M3 - Article

AN - SCOPUS:0017504151

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JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

SN - 0969-8043

IS - 6

ER -

The preparation of astatotyrosine

Abstract

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