The preparation of astatotyrosine

Andrew T M Vaughan, J. H. Fremlin

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

The reaction between astatine, an artificially produced halogen, and the l-amino acid tyrosine, has been investigated. Results of kinetic analyses confirm an electrophilic mechanism for astatotyrosine production, similar to that proposed for iodotyrosine. Studies on the stability of the resulting compound are presented with special reference to the potential in vivo uses for the alpha-emitting isotope 211At, attached to the tyrosine component of biologically active proteins.

Original languageEnglish (US)
Pages (from-to)595-598
Number of pages4
JournalThe International Journal Of Applied Radiation And Isotopes
Volume28
Issue number6
DOIs
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Radiation

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