The preparation and cytotoxic properties of211at labelled concanavalin a bound to cell membranes

Andrew T M Vaughan, W. Bateman, J. Cowan

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


A method of labelling biologically active proteins with the alpha emmitting halogen211At is presented. The labelling procedure is discussed with reference to the chemistry of astatine. Proteins which have been labelled retain approximately 50% of their original biological activity. Using cell specific labelled proteins, dose response curves are given indicating that such reagents are extremely cytotoxic, D37 human CML cells=5 atmos211At/cell. The research potential of211At labelled biologically active proteins is briefly discussed.

Original languageEnglish (US)
Pages (from-to)33-39
Number of pages7
JournalJournal of Radioanalytical Chemistry
Issue number1-2
StatePublished - Mar 1981
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Molecular Medicine


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