The preparation and cytotoxic properties of211at labelled concanavalin a bound to cell membranes

Andrew T M Vaughan, W. Bateman, J. Cowan

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A method of labelling biologically active proteins with the alpha emmitting halogen211At is presented. The labelling procedure is discussed with reference to the chemistry of astatine. Proteins which have been labelled retain approximately 50% of their original biological activity. Using cell specific labelled proteins, dose response curves are given indicating that such reagents are extremely cytotoxic, D37 human CML cells=5 atmos211At/cell. The research potential of211At labelled biologically active proteins is briefly discussed.

Original languageEnglish (US)
Pages (from-to)33-39
Number of pages7
JournalJournal of Radioanalytical Chemistry
Volume64
Issue number1-2
DOIs
StatePublished - Mar 1981
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Molecular Medicine

Fingerprint Dive into the research topics of 'The preparation and cytotoxic properties of<sup>211</sup>at labelled concanavalin a bound to cell membranes'. Together they form a unique fingerprint.

  • Cite this