The potter's wheel: The host's role in sculpting its microbiota

Charles L Bevins, Nita H. Salzman

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Animals, ranging from basal metazoans to primates, are host to complex microbial ecosystems; engaged in a symbiotic relationship that is essential for host physiology and homeostasis. Epithelial surfaces vary in the composition of colonizing microbiota as one compares anatomic sites, developmental stages and species origin. Alterations of microbial composition likely contribute to susceptibility to several distinct diseases. The forces that shape the colonizing microbial composition are the focus of much current investigation, and it is evident that there are pressures exerted both by the host and the external environment to mold these ecosystems. The focus of this review is to discuss recent studies that demonstrate the critical importance of host factors in selecting for its microbiome. Greater insight into host-microbiome interactions will be essential for understanding homeostasis at mucosal surfaces, and developing useful interventions when homeostasis is disrupted.

Original languageEnglish (US)
Pages (from-to)3675-3685
Number of pages11
JournalCellular and Molecular Life Sciences
Volume68
Issue number22
DOIs
StatePublished - Nov 2011

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Keywords

  • Antimicrobial peptide
  • Bacteria
  • Defensin
  • Dysbiosis
  • Homeostasis
  • Immunoglobulin a
  • Intestine
  • Microbial colonization
  • Microflora
  • Mucosa
  • Mucus

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

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