The Potential of Flavanol and Procyanidin Intake to Influence Age-Related Vascular Disease

Roberta R. Holt, Christian Heiss, Malte Kelm, Carl L Keen

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Advancing age is an independent major risk factor for cardiovascular disease (CVD). Age-associated impairments in the control of inflammation, excessive oxidative stress, and reduced cellular repair can all contribute to the development and progression of CVD. Current recommendations for both the primary and secondary prevention of CVD promote lifestyle modifications that include the adoption of healthy dietary patterns, such as the consumption of diets rich in plant foods, as these have been associated with a lower lifetime risk for the development of CVD. The potential for a diet rich in plant foods to be cardiovascular protective is also supported by prospective studies that suggest the intake of foods providing high amounts of certain phytochemicals, in particular flavanols and procyanidins, reduce the risk for CVD. These observations are further supported by a number of dietary intervention trials that show improvements in vascular function and reduced platelet reactivity following the consumption of high flavanol foods. In the current article we review a selection of these studies, and comment on some of the potential mechanisms that have been postulated to underlie the health effects of flavanol and procyanidin-rich foods.

Original languageEnglish (US)
Pages (from-to)290-323
Number of pages34
JournalJournal of Nutrition in Gerontology and Geriatrics
Volume31
Issue number3
DOIs
StatePublished - Jul 2012

Fingerprint

Vascular Diseases
Cardiovascular Diseases
Edible Plants
Diet
Food
Proanthocyanidins
Phytochemicals
Primary Prevention
Secondary Prevention
Blood Vessels
Life Style
Oxidative Stress
Blood Platelets
Eating
procyanidin
Prospective Studies
Inflammation
Health

Keywords

  • age
  • cardiovascular
  • epicatechin
  • flavanol
  • procyanidin

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Nutrition and Dietetics

Cite this

The Potential of Flavanol and Procyanidin Intake to Influence Age-Related Vascular Disease. / Holt, Roberta R.; Heiss, Christian; Kelm, Malte; Keen, Carl L.

In: Journal of Nutrition in Gerontology and Geriatrics, Vol. 31, No. 3, 07.2012, p. 290-323.

Research output: Contribution to journalArticle

Holt, Roberta R. ; Heiss, Christian ; Kelm, Malte ; Keen, Carl L. / The Potential of Flavanol and Procyanidin Intake to Influence Age-Related Vascular Disease. In: Journal of Nutrition in Gerontology and Geriatrics. 2012 ; Vol. 31, No. 3. pp. 290-323.
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