Abstract
The use of injected stem cells, leading to regeneration of ischemic heart tissue, for example, following coronary artery occlusion, has emerged as a major new option for managing 'heart attack' patients. While some clinical trials have been encouraging, there have also been failures and there is little understanding of the multiplicity of factors that lead to the outcome. In this overview paper, the opportunities and challenges in applying biophotonic techniques to regenerative medicine, exemplified by the challenge of stem cell therapy of ischemic heart disease, are considered. The focus is on optical imaging to track stem cell distribution and fate, and optical spectroscopies and/or imaging to monitor the structural remodeling of the tissue and the resulting functional changes. The scientific, technological, and logistics issues involved in moving some of these techniques from pre-clinical research mode ultimately into the clinic are also highlighted.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 669-681 |
| Number of pages | 13 |
| Journal | Journal of Biophotonics |
| Volume | 2 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2009 |
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Keywords
- Biophotonics
- Cardiac
- Optical imaging
- Optical spectroscopy
- Regeneration
- Stem cells
ASJC Scopus subject areas
- Materials Science(all)
- Engineering(all)
- Physics and Astronomy(all)
- Chemistry(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
The potential of biophotonic techniques in stem cell tracking and monitoring of tissue regeneration applied to cardiac stem cell therapy. / Wilson, Brian C.; Vitkin, I. Alex; Matthews, Dennis L.
In: Journal of Biophotonics, Vol. 2, No. 11, 11.2009, p. 669-681.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The potential of biophotonic techniques in stem cell tracking and monitoring of tissue regeneration applied to cardiac stem cell therapy
AU - Wilson, Brian C.
AU - Vitkin, I. Alex
AU - Matthews, Dennis L
PY - 2009/11
Y1 - 2009/11
N2 - The use of injected stem cells, leading to regeneration of ischemic heart tissue, for example, following coronary artery occlusion, has emerged as a major new option for managing 'heart attack' patients. While some clinical trials have been encouraging, there have also been failures and there is little understanding of the multiplicity of factors that lead to the outcome. In this overview paper, the opportunities and challenges in applying biophotonic techniques to regenerative medicine, exemplified by the challenge of stem cell therapy of ischemic heart disease, are considered. The focus is on optical imaging to track stem cell distribution and fate, and optical spectroscopies and/or imaging to monitor the structural remodeling of the tissue and the resulting functional changes. The scientific, technological, and logistics issues involved in moving some of these techniques from pre-clinical research mode ultimately into the clinic are also highlighted.
AB - The use of injected stem cells, leading to regeneration of ischemic heart tissue, for example, following coronary artery occlusion, has emerged as a major new option for managing 'heart attack' patients. While some clinical trials have been encouraging, there have also been failures and there is little understanding of the multiplicity of factors that lead to the outcome. In this overview paper, the opportunities and challenges in applying biophotonic techniques to regenerative medicine, exemplified by the challenge of stem cell therapy of ischemic heart disease, are considered. The focus is on optical imaging to track stem cell distribution and fate, and optical spectroscopies and/or imaging to monitor the structural remodeling of the tissue and the resulting functional changes. The scientific, technological, and logistics issues involved in moving some of these techniques from pre-clinical research mode ultimately into the clinic are also highlighted.
KW - Biophotonics
KW - Cardiac
KW - Optical imaging
KW - Optical spectroscopy
KW - Regeneration
KW - Stem cells
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UR - http://www.scopus.com/inward/citedby.url?scp=74049111464&partnerID=8YFLogxK
U2 - 10.1002/jbio.200910079
DO - 10.1002/jbio.200910079
M3 - Article
C2 - 19787683
AN - SCOPUS:74049111464
VL - 2
SP - 669
EP - 681
JO - Journal of Biophotonics
JF - Journal of Biophotonics
SN - 1864-063X
IS - 11
ER -