The potential molecular effects of bursal septpeptide II on immune induction and antitumor activity

Guang Fang Zhou, Qing Tao Liu, Bin Zhou, Ya Feng Qiu, Xiao Dong Liu, Zhi Yong Ma, Xiuli Feng, Rui Bing Cao, Pu Yan Chen

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The bursa of Fabricius (BF) is the acknowledged central humoral immune organ in birds. Bursal septpeptide II (BSP-II) is an immunomodulatory bioactive peptide isolated from BF. To understand the effects of BSP-II on immune induction, gene expression profiles of hybridoma cells treated with BSP-II were evaluated. Pathway analysis showed that regulated genes were involved in cytokine-cytokine receptor interactions, T cell receptor signaling pathway, and pathway in cancer. It was observed that BSP-II reduced tumor cells proliferation and stimulated p53 expression. These results indicate potential mechanisms underlying the effects of the humoral immune system on immune induction, including antitumor activities. Our study has provided a novel insight into immunotherapeutic strategies for treating human tumors.

Original languageEnglish (US)
Pages (from-to)325-331
Number of pages7
JournalJournal of Veterinary Science
Volume16
Issue number3
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Bursal septpeptide II
  • Humoral immune system
  • Pathway analysis
  • Tumor suppressor p53

ASJC Scopus subject areas

  • veterinary(all)

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  • Cite this

    Zhou, G. F., Liu, Q. T., Zhou, B., Qiu, Y. F., Liu, X. D., Ma, Z. Y., Feng, X., Cao, R. B., & Chen, P. Y. (2015). The potential molecular effects of bursal septpeptide II on immune induction and antitumor activity. Journal of Veterinary Science, 16(3), 325-331. https://doi.org/10.4142/jvs.2015.16.3.325