The potential mechanism of Bursal-derived BPP-II on the antibody production and avian pre-B cell

Xiuli Feng, Ruibing Cao, Bin Zhou, Qingtao Liu, Ke Liu, Xiaodong Liu, Yuanpeng Zhang, Jinyan Gu, Denian Miao, Puyan Chen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The bursa of Fabricius is critical for the normal development of the B lymphocytes responsible for antibody production. However, the mechanism of the bursal-derived bioactive factor on B cell development is little reported. In this paper, chicks were immunized with BPP-II and AIV vaccine or AIV antigen, and antibody and IL-4 production were detected. The results showed that BPP-II played strongly inducing roles on the humoral immune responses. To investigate the gene expression at transcriptional level, avian pre-B lymphocyte DT40 cells were treated with BPP-II, and were analyzed with the gene microarray. The results proved that BPP-II treatment regulated 11 pathways, in which homologous recombination is a vital mechanism which is involved in antibody Ig gene conversion and diversification during B cell development. These results suggested Bursal-derived biological active factor BPP-II might be involved in the antibody production processes and B cell development, which is vital to the humoral central immune organ, the bursa of Fabricius.

Original languageEnglish (US)
Pages (from-to)1535-1539
Number of pages5
JournalVaccine
Volume31
Issue number11
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

bradykinin potentiating factors
B-Lymphoid Precursor Cells
antibody formation
B-lymphocytes
Antibody Formation
B-Lymphocytes
Bursa of Fabricius
bursa of Fabricius
Gene Conversion
Immunoglobulin Genes
antibodies
gene conversion
Antibodies
Homologous Recombination
homologous recombination
Biological Factors
interleukin-4
Humoral Immunity
humoral immunity
Interleukin-4

Keywords

  • Antibody production
  • BPP-II
  • Gene microarray
  • Homologous recombination

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

The potential mechanism of Bursal-derived BPP-II on the antibody production and avian pre-B cell. / Feng, Xiuli; Cao, Ruibing; Zhou, Bin; Liu, Qingtao; Liu, Ke; Liu, Xiaodong; Zhang, Yuanpeng; Gu, Jinyan; Miao, Denian; Chen, Puyan.

In: Vaccine, Vol. 31, No. 11, 01.01.2013, p. 1535-1539.

Research output: Contribution to journalArticle

Feng, X, Cao, R, Zhou, B, Liu, Q, Liu, K, Liu, X, Zhang, Y, Gu, J, Miao, D & Chen, P 2013, 'The potential mechanism of Bursal-derived BPP-II on the antibody production and avian pre-B cell', Vaccine, vol. 31, no. 11, pp. 1535-1539. https://doi.org/10.1016/j.vaccine.2012.09.022
Feng, Xiuli ; Cao, Ruibing ; Zhou, Bin ; Liu, Qingtao ; Liu, Ke ; Liu, Xiaodong ; Zhang, Yuanpeng ; Gu, Jinyan ; Miao, Denian ; Chen, Puyan. / The potential mechanism of Bursal-derived BPP-II on the antibody production and avian pre-B cell. In: Vaccine. 2013 ; Vol. 31, No. 11. pp. 1535-1539.
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