The potential mechanism of Bursal-derived BPP-II on the antibody production and avian pre-B cell

Xiuli Feng, Ruibing Cao, Bin Zhou, Qingtao Liu, Ke Liu, Xiaodong Liu, Yuanpeng Zhang, Jinyan Gu, Denian Miao, Puyan Chen

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The bursa of Fabricius is critical for the normal development of the B lymphocytes responsible for antibody production. However, the mechanism of the bursal-derived bioactive factor on B cell development is little reported. In this paper, chicks were immunized with BPP-II and AIV vaccine or AIV antigen, and antibody and IL-4 production were detected. The results showed that BPP-II played strongly inducing roles on the humoral immune responses. To investigate the gene expression at transcriptional level, avian pre-B lymphocyte DT40 cells were treated with BPP-II, and were analyzed with the gene microarray. The results proved that BPP-II treatment regulated 11 pathways, in which homologous recombination is a vital mechanism which is involved in antibody Ig gene conversion and diversification during B cell development. These results suggested Bursal-derived biological active factor BPP-II might be involved in the antibody production processes and B cell development, which is vital to the humoral central immune organ, the bursa of Fabricius.

Original languageEnglish (US)
Pages (from-to)1535-1539
Number of pages5
JournalVaccine
Volume31
Issue number11
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Keywords

  • Antibody production
  • BPP-II
  • Gene microarray
  • Homologous recombination

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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  • Cite this

    Feng, X., Cao, R., Zhou, B., Liu, Q., Liu, K., Liu, X., Zhang, Y., Gu, J., Miao, D., & Chen, P. (2013). The potential mechanism of Bursal-derived BPP-II on the antibody production and avian pre-B cell. Vaccine, 31(11), 1535-1539. https://doi.org/10.1016/j.vaccine.2012.09.022