The polymer-supported Cadiot-Chodkiewicz coupling of acetylenes to produce unsymmetrical diynes

John M. Montierth, Dierdre R. DeMario, Mark J. Kurth, Neil E. Schore

Research output: Contribution to journal › Article

75 Citations (Scopus)

Abstract

Cu(II)-catalyzed coupling of polymer-bound' ω-haloalkyn-1-ols to terminal alkynes proceeds in moderate yield to give unsymmetrical diynes upon hydrolytic removal from the polymer. Formation of the symmetrical homocoupled byproduct is suppressed relative to conventional Cadiot-Chodkiewicz conditions in homogeneous solution.

Original languageEnglish (US)
Pages (from-to)11741-11748
Number of pages8
JournalTetrahedron
Volume54
Issue number39
DOIs
StatePublished - Sep 24 1998

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Diynes
Alkynes
Polymers
Byproducts

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

The polymer-supported Cadiot-Chodkiewicz coupling of acetylenes to produce unsymmetrical diynes. / Montierth, John M.; DeMario, Dierdre R.; Kurth, Mark J.; Schore, Neil E.

In: Tetrahedron, Vol. 54, No. 39, 24.09.1998, p. 11741-11748.

Research output: Contribution to journal › Article

Montierth, JM, DeMario, DR, Kurth, MJ & Schore, NE 1998, 'The polymer-supported Cadiot-Chodkiewicz coupling of acetylenes to produce unsymmetrical diynes', Tetrahedron, vol. 54, no. 39, pp. 11741-11748. https://doi.org/10.1016/S0040-4020(98)83035-4
Montierth JM, DeMario DR, Kurth MJ, Schore NE. The polymer-supported Cadiot-Chodkiewicz coupling of acetylenes to produce unsymmetrical diynes. Tetrahedron. 1998 Sep 24;54(39):11741-11748. https://doi.org/10.1016/S0040-4020(98)83035-4
Montierth, John M. ; DeMario, Dierdre R. ; Kurth, Mark J. ; Schore, Neil E. / The polymer-supported Cadiot-Chodkiewicz coupling of acetylenes to produce unsymmetrical diynes. In: Tetrahedron. 1998 ; Vol. 54, No. 39. pp. 11741-11748.
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