The polymer-supported Cadiot-Chodkiewicz coupling of acetylenes to produce unsymmetrical diynes

John M. Montierth, Dierdre R. DeMario, Mark J. Kurth, Neil E. Schore

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

Cu(II)-catalyzed coupling of polymer-bound' ω-haloalkyn-1-ols to terminal alkynes proceeds in moderate yield to give unsymmetrical diynes upon hydrolytic removal from the polymer. Formation of the symmetrical homocoupled byproduct is suppressed relative to conventional Cadiot-Chodkiewicz conditions in homogeneous solution.

Original languageEnglish (US)
Pages (from-to)11741-11748
Number of pages8
JournalTetrahedron
Volume54
Issue number39
DOIs
StatePublished - Sep 24 1998

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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