Abstract
Cu(II)-catalyzed coupling of polymer-bound' ω-haloalkyn-1-ols to terminal alkynes proceeds in moderate yield to give unsymmetrical diynes upon hydrolytic removal from the polymer. Formation of the symmetrical homocoupled byproduct is suppressed relative to conventional Cadiot-Chodkiewicz conditions in homogeneous solution.
Original language | English (US) |
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Pages (from-to) | 11741-11748 |
Number of pages | 8 |
Journal | Tetrahedron |
Volume | 54 |
Issue number | 39 |
DOIs | |
State | Published - Sep 24 1998 |
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery