The Polycomb group in Caenorhabditis elegans and maternal control of germline development

Ian F Korf, Yuan Fan, Susan Strome

Research output: Contribution to journalArticle

119 Scopus citations

Abstract

Four Caenorhabditis elegans genes, mes-2, mes-3, mes-4 and mes-6, are essential for normal proliferation and viability of the germline. Mutations in these genes cause a maternal-effect sterile (i.e. mes) or grandchildless phenotype. We report that the mes-6 gene is in an unusual operon, the second example of this type of operon in C. elegans, and encodes the nematode homolog of Extra sex combs, a WD-40 protein in the Polycomb group in Drosophila. mes-2 encodes another Polycomb group protein. Consistent with the known role of Polycomb group proteins in regulating gene expression, MES-6 is a nuclear protein. It is enriched in the germline of larvae and adults and is present in all nuclei of early embryos. Molecular epistasis results predict that the MES proteins, like Polycomb group proteins in complex to regulate gene searches reveal that there are considerably fewer Polycomb group genes in C. elegans than in Drosophila or vertebrates, and our studies suggest that their primary function is in controlling gene expression in the germline and ensuring the survival and proliferation of that tissue.

Original languageEnglish (US)
Pages (from-to)2469-2478
Number of pages10
JournalDevelopment
Volume125
Issue number13
StatePublished - Jul 1998
Externally publishedYes

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Keywords

  • Caenorhabditis elegans
  • mes genes
  • Polycomb group

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

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