The plausibility of maternal nutritional status being a contributing factor to the risk for fetal alcohol spectrum disorders: The potential influence of zinc status as an example

Carl L Keen, Janet Y. Uriu-Adams, Anatoly Skalny, Andrei Grabeklis, Sevil Grabeklis, Kerri Green, Lyubov Yevtushok, Wladimir W. Wertelecki, Christina D. Chambers

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

There is increasing evidence that human pregnancy outcome can be significantly compromised by suboptimal maternal nutritional status. Poor diet results in a maternal-fetal environment in which the teratogenicity of other insults such as alcohol might be amplified. As an example, there is evidence that zinc (Zn) can interact with maternal alcohol exposure to influence the risk for fetal alcohol spectrum disorders (FASD). Studies with experimental animals have shown that the teratogenicity of alcohol is increased under conditions of Zn deficiency, whereas its teratogenicity is lessened when animals are given Zn-supplemented diets or Zn injections before the alcohol exposure. Alcohol can precipitate an acute-phase response, resulting in a subsequent increase in maternal liver metallothionein, which can sequester Zn and lead to decreased Zn transfer to the fetus. Importantly, the teratogenicity of acute alcohol exposure is reduced in metallothionein knockout mice, which can have improved Zn transfer to the conceptus relative to wild-type mice. Consistent with the above, Zn status has been reported to be low in alcoholic women at delivery. Preliminary data from two basic science and clinical nutritional studies that are ongoing as part of the international Collaborative Initiative on Fetal Alcohol Spectrum Disorders support the potential role of Zn, among other nutritional factors, relative to risk for FASD. Importantly, the nutrient levels being examined in these studies are relevant to general clinical populations and represent suboptimal levels rather than severe deficiencies. These data suggest that moderate deficiencies in single nutrients can act as permissive factors for FASD, and that adequate nutritional status or intervention through supplementation may provide protection from some of the adverse effects of prenatal alcohol exposure.

Original languageEnglish (US)
Pages (from-to)125-135
Number of pages11
JournalBioFactors
Volume36
Issue number2
DOIs
StatePublished - 2010

Fingerprint

Fetal Alcohol Spectrum Disorders
Nutritional Status
Zinc
Alcohols
Mothers
Metallothionein
Nutrition
Nutrients
Nutritional Sciences
Diet
Animals
Maternal Exposure
Food
Acute-Phase Reaction
Alcoholics
Pregnancy Outcome
Knockout Mice
Fetus
Liver
Precipitates

Keywords

  • Alcohol
  • FAS
  • FASD
  • Micronutrients
  • Pregnancy
  • Zinc

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

The plausibility of maternal nutritional status being a contributing factor to the risk for fetal alcohol spectrum disorders : The potential influence of zinc status as an example. / Keen, Carl L; Uriu-Adams, Janet Y.; Skalny, Anatoly; Grabeklis, Andrei; Grabeklis, Sevil; Green, Kerri; Yevtushok, Lyubov; Wertelecki, Wladimir W.; Chambers, Christina D.

In: BioFactors, Vol. 36, No. 2, 2010, p. 125-135.

Research output: Contribution to journalArticle

Keen, CL, Uriu-Adams, JY, Skalny, A, Grabeklis, A, Grabeklis, S, Green, K, Yevtushok, L, Wertelecki, WW & Chambers, CD 2010, 'The plausibility of maternal nutritional status being a contributing factor to the risk for fetal alcohol spectrum disorders: The potential influence of zinc status as an example', BioFactors, vol. 36, no. 2, pp. 125-135. https://doi.org/10.1002/biof.89
Keen, Carl L ; Uriu-Adams, Janet Y. ; Skalny, Anatoly ; Grabeklis, Andrei ; Grabeklis, Sevil ; Green, Kerri ; Yevtushok, Lyubov ; Wertelecki, Wladimir W. ; Chambers, Christina D. / The plausibility of maternal nutritional status being a contributing factor to the risk for fetal alcohol spectrum disorders : The potential influence of zinc status as an example. In: BioFactors. 2010 ; Vol. 36, No. 2. pp. 125-135.
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