The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos

Craig C. Mello, Bruce W. Draper, Michael Krause, Harold Weintraub, James R. Priess

Research output: Contribution to journalArticle

180 Scopus citations

Abstract

During C. elegans embryogenesis an 8-cell stage blastomere, called MS, undergoes a reproducible cleavage pattern, producing pharyngeal cells, body wall muscles, and cell deaths. We show here that maternal-effect mutations in the pie-1 and mex-1 genes cause additional 8-cell stage blastomeres to adopt a fate very similar to that of the wild-type MS blastomere. In pie-1 mutants one additional posterior blastomere adopts an MS-like fate, and in mex-1 mutants four additional anterior blastomeres adopt an MS-like fate. We propose that maternally provided pie-1(+) and mex-1(+) gene products may function in the early embryo to localize or regulate factors that determine the fate of the MS blastomere.

Original languageEnglish (US)
Pages (from-to)163-176
Number of pages14
JournalCell
Volume70
Issue number1
DOIs
StatePublished - Jul 10 1992
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Mello, C. C., Draper, B. W., Krause, M., Weintraub, H., & Priess, J. R. (1992). The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos. Cell, 70(1), 163-176. https://doi.org/10.1016/0092-8674(92)90542-K