The physics of lamellipodial protrusion

Alexander Mogilner, George Oster

Research output: Contribution to journalArticle

77 Scopus citations

Abstract

Many cell movements appear to be driven by the polymerization of actin. Here we show how the force of polymerization can be generated by the thermal motions of the actin filaments near the sites of polymerization. We apply the model to explain the observations that the lamellipodial cytoskeleton is organized into an orthogonal network interspersed with filopodial protrusions, and that the protrusion of lamellipodia generally proceeds in the presence of a rearward cytoskeletal flow.

Original languageEnglish (US)
Pages (from-to)47-53
Number of pages7
JournalEuropean Biophysics Journal
Volume25
Issue number1
DOIs
StatePublished - 1996

ASJC Scopus subject areas

  • Biophysics

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