The pharmacology and toxicology of three new biologic agents used in pulmonary medicine

Timothy E Albertson, William F. Walby, Roblee P Allen, R. Steven Tharratt

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Biological agents have played an important role in the evolution of modern medical therapeutics. Recent advances in biologicals have in part been stimulated by the biotechnology revolution seen over the last several years. Toxicologists need to be aware of the proposed mechanisms and approved and experimental uses of these new biologic agents. Further, controversies about their use, efficacy, cost issues and potential toxicities should be known. Often these drugs are designed for small patient populations thus limiting the availability of human toxicological data bases. This paper reviews the pharmacology and toxicology of three new biologies (recombinant human DNase I, alpha 1-protease inhibitor, and nitric oxide). These agents appear to have important roles in treating specific diseases or disease states seen in pulmonary medicine.

Original languageEnglish (US)
Pages (from-to)427-438
Number of pages12
JournalClinical Toxicology
Issue number5
StatePublished - 1995


  • Alpha 1-antitrypsin
  • Alpha 1-protease inhibitor
  • Deoxvribnonuclease I
  • DNA. Recombinant
  • Dornase. Alpha
  • Nitric oxide
  • RhDNase

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis


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