The pharmacokinetics of a single intramuscular dose of amikacin in red-tailed hawks (Buteo jamaicensis)

R. Brooks Bloomfield, Dale Brooks, Philip R Vulliet

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The pharmacokinetic parameters of amikacin were determined in red-tailed hawks (Buteo jamaicensis) following the i.m. administration of a single 20 mg/kg dose. After a rapid absorption phase, mean amikacin serum concentrations peaked at 65 ± 12 μg/ml 30-45 min following injection. The serum amikacin concentrations decreased to 2.3 ± 2 μg/ml at 12 hr postinjection. Amikacin was eliminated with first-order kinetics characteristic of a single-compartment model with a half-life of 2.02 ± 0.63 hr. The volume of distribution was estimated to be 0.28 ± 0.03 L/kg. Forty-two isolates of gram-negative bacteria and coagulase-positive Staphylococcus species were cultured from birds of prey presented to the Veterinary Medical Teaching Hospital at the University of California-Davis. The minimum inhibitory concentration (MICs) of amikacin ranged from 0.5 to 8.0 μg/ml (x̄ = 2.5 μg/ml). The 20 mg/kg dose used in this study resulted in serum concentrations at or above the MICs for >12 hr for most of the isolates examined. The heaviest birds had the lowest peak serum amikacin concentrations, and the lightest birds had the highest, despite exact volume replacement for each sample drawn. This observation suggests that doses should be based on factors other than weight alone. Amikacin administered at 15-20 mg/kg/day, either as a single dose or divided into two or three doses, is effective in treating sensitive pathogens of the red-tailed hawk.

Original languageEnglish (US)
Pages (from-to)55-61
Number of pages7
JournalJournal of Zoo and Wildlife Medicine
Volume28
Issue number1
StatePublished - Mar 1997

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Hawks
Buteo jamaicensis
amikacin
Amikacin
pharmacokinetics
Pharmacokinetics
serum
dosage
Microbial Sensitivity Tests
minimum inhibitory concentration
Serum
bird
Birds
Raptors
half life
coagulase positive staphylococci
teaching
Coagulase
birds
pathogen

Keywords

  • Amikacin
  • Buteo jamaicensis
  • Pharmacokinetics
  • Red-tailed hawk

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Environmental Science(all)
  • veterinary(all)

Cite this

The pharmacokinetics of a single intramuscular dose of amikacin in red-tailed hawks (Buteo jamaicensis). / Bloomfield, R. Brooks; Brooks, Dale; Vulliet, Philip R.

In: Journal of Zoo and Wildlife Medicine, Vol. 28, No. 1, 03.1997, p. 55-61.

Research output: Contribution to journalArticle

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