The pattern of electrolyte excretion in normal and hypertensive subjects before and after saline infusions. A simple electrolyte formula for the diagnosis of primary aldosteronism

A. Richard Christlieb, Eric A. Espiner, Ezra A Amsterdam, Paul I. Jagger, Saul J. Dobrzinsky, David P. Lauler, Roger B. Hickler

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Electrolyte excretion and serum electrolytes were studied in 99 subjects-19 normal subjects, 62 patients with essential hypertension, 10 with hypertension and renal disease, and 8 patients with primary aldosteronism-during administration of a low sodium diet and during 2 days of intravenous sodium loading. With saline infusions patients with primary aldosteronism gained significantly less weight, excreted significantly more potassium on each day of infusion, and excreted significantly more sodium on the first day of infusion only, than the other groups studied. Mean serum potassium levels fell significantly with saline infusions in patients with primary aldosteronism but remained unchanged in the other groups. From these observations a diagnostic formula based on potassium clearance corrected for sodium excretion was derived by which patients with primary aldosteronism could be separated completely from the other groups, with the exception of 1 patient with renal disease. Although patients with primary aldosteronism tended to have lower salivary sodium/potassium ratios than patients with essential hypertension, the difference was not significant.

Original languageEnglish (US)
Pages (from-to)595-601
Number of pages7
JournalThe American journal of cardiology
Volume27
Issue number6
DOIs
StatePublished - 1971
Externally publishedYes

Fingerprint

Hyperaldosteronism
Electrolytes
Potassium
Sodium
Sodium-Restricted Diet
Renal Hypertension
Serum
Kidney
Weights and Measures

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

The pattern of electrolyte excretion in normal and hypertensive subjects before and after saline infusions. A simple electrolyte formula for the diagnosis of primary aldosteronism. / Christlieb, A. Richard; Espiner, Eric A.; Amsterdam, Ezra A; Jagger, Paul I.; Dobrzinsky, Saul J.; Lauler, David P.; Hickler, Roger B.

In: The American journal of cardiology, Vol. 27, No. 6, 1971, p. 595-601.

Research output: Contribution to journalArticle

Christlieb, A. Richard ; Espiner, Eric A. ; Amsterdam, Ezra A ; Jagger, Paul I. ; Dobrzinsky, Saul J. ; Lauler, David P. ; Hickler, Roger B. / The pattern of electrolyte excretion in normal and hypertensive subjects before and after saline infusions. A simple electrolyte formula for the diagnosis of primary aldosteronism. In: The American journal of cardiology. 1971 ; Vol. 27, No. 6. pp. 595-601.
@article{f2807ac7fc1a47919ccc5ba7ba11bdaa,
title = "The pattern of electrolyte excretion in normal and hypertensive subjects before and after saline infusions. A simple electrolyte formula for the diagnosis of primary aldosteronism",
abstract = "Electrolyte excretion and serum electrolytes were studied in 99 subjects-19 normal subjects, 62 patients with essential hypertension, 10 with hypertension and renal disease, and 8 patients with primary aldosteronism-during administration of a low sodium diet and during 2 days of intravenous sodium loading. With saline infusions patients with primary aldosteronism gained significantly less weight, excreted significantly more potassium on each day of infusion, and excreted significantly more sodium on the first day of infusion only, than the other groups studied. Mean serum potassium levels fell significantly with saline infusions in patients with primary aldosteronism but remained unchanged in the other groups. From these observations a diagnostic formula based on potassium clearance corrected for sodium excretion was derived by which patients with primary aldosteronism could be separated completely from the other groups, with the exception of 1 patient with renal disease. Although patients with primary aldosteronism tended to have lower salivary sodium/potassium ratios than patients with essential hypertension, the difference was not significant.",
author = "Christlieb, {A. Richard} and Espiner, {Eric A.} and Amsterdam, {Ezra A} and Jagger, {Paul I.} and Dobrzinsky, {Saul J.} and Lauler, {David P.} and Hickler, {Roger B.}",
year = "1971",
doi = "10.1016/0002-9149(71)90222-0",
language = "English (US)",
volume = "27",
pages = "595--601",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - The pattern of electrolyte excretion in normal and hypertensive subjects before and after saline infusions. A simple electrolyte formula for the diagnosis of primary aldosteronism

AU - Christlieb, A. Richard

AU - Espiner, Eric A.

AU - Amsterdam, Ezra A

AU - Jagger, Paul I.

AU - Dobrzinsky, Saul J.

AU - Lauler, David P.

AU - Hickler, Roger B.

PY - 1971

Y1 - 1971

N2 - Electrolyte excretion and serum electrolytes were studied in 99 subjects-19 normal subjects, 62 patients with essential hypertension, 10 with hypertension and renal disease, and 8 patients with primary aldosteronism-during administration of a low sodium diet and during 2 days of intravenous sodium loading. With saline infusions patients with primary aldosteronism gained significantly less weight, excreted significantly more potassium on each day of infusion, and excreted significantly more sodium on the first day of infusion only, than the other groups studied. Mean serum potassium levels fell significantly with saline infusions in patients with primary aldosteronism but remained unchanged in the other groups. From these observations a diagnostic formula based on potassium clearance corrected for sodium excretion was derived by which patients with primary aldosteronism could be separated completely from the other groups, with the exception of 1 patient with renal disease. Although patients with primary aldosteronism tended to have lower salivary sodium/potassium ratios than patients with essential hypertension, the difference was not significant.

AB - Electrolyte excretion and serum electrolytes were studied in 99 subjects-19 normal subjects, 62 patients with essential hypertension, 10 with hypertension and renal disease, and 8 patients with primary aldosteronism-during administration of a low sodium diet and during 2 days of intravenous sodium loading. With saline infusions patients with primary aldosteronism gained significantly less weight, excreted significantly more potassium on each day of infusion, and excreted significantly more sodium on the first day of infusion only, than the other groups studied. Mean serum potassium levels fell significantly with saline infusions in patients with primary aldosteronism but remained unchanged in the other groups. From these observations a diagnostic formula based on potassium clearance corrected for sodium excretion was derived by which patients with primary aldosteronism could be separated completely from the other groups, with the exception of 1 patient with renal disease. Although patients with primary aldosteronism tended to have lower salivary sodium/potassium ratios than patients with essential hypertension, the difference was not significant.

UR - http://www.scopus.com/inward/record.url?scp=0015073438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015073438&partnerID=8YFLogxK

U2 - 10.1016/0002-9149(71)90222-0

DO - 10.1016/0002-9149(71)90222-0

M3 - Article

C2 - 5088765

AN - SCOPUS:0015073438

VL - 27

SP - 595

EP - 601

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 6

ER -