The Pathways Study: A prospective study of breast cancer survivorship within Kaiser Permanente Northern California

Marilyn L. Kwan, Christine B. Ambrosone, Marion M. Lee, Janice Barlow, Sarah E. Krathwohl, Isaac Joshua Ergas, Christine H. Ashley, Julie R. Bittner, Jeanne Darbinian, Keren Stronach, Bette J. Caan, Warren Davis, Susan E. Kutner, Charles P. Quesenberry, Carol P. Somkin, Barbara Sternfeld, John K. Wiencke, Shichun Zheng, Lawrence H. Kushi

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Objective: With 2.3 million breast cancer survivors in the US today, identification of modifiable factors associated with breast cancer recurrence and survival is increasingly important. Only recently new studies have been designed to examine the impact of lifestyle factors on prognosis, including Pathways, a prospective study of women with breast cancer in Kaiser Permanente Northern California (KPNC). Methods: Pathways aims to examine the effect on recurrence and survival of (1) lifestyle factors such as diet, physical activity, quality of life, and use of alternative therapies and (2) molecular factors such as genetic polymorphisms involved in metabolism of chemotherapeutic agents. Eligibility includes any woman diagnosed with invasive breast cancer within KPNC, no previous diagnosis of other invasive cancer, age 21 years or older, and ability to speak English, Spanish, Cantonese, or Mandarin. Newly diagnosed patients are identified daily from electronic pathology records and are enrolled within two months of diagnosis. An extensive baseline interview is conducted, blood and saliva samples are collected, and body measurements are taken. Women are followed for lifestyle updates, treatment, and outcomes by self-report and query of KPNC databases. Results: Recruitment began in 9 January, 2006, and as of 16 January, 2008, 1,539 women have been enrolled along with collection of 1,323 blood samples (86%) and 1,398 saliva samples (91%). Conclusions: The Pathways Study will become a rich resource to examine behavioral and molecular factors and breast cancer prognosis.

Original languageEnglish (US)
Pages (from-to)1065-1076
Number of pages12
JournalCancer Causes and Control
Volume19
Issue number10
DOIs
StatePublished - Dec 2008
Externally publishedYes

Fingerprint

Survival Rate
Prospective Studies
Breast Neoplasms
Life Style
Saliva
Recurrence
Aptitude
Survival
Genetic Polymorphisms
Complementary Therapies
Self Report
Survivors
Quality of Life
Databases
Interviews
Exercise
Pathology
Diet
Neoplasms

Keywords

  • Breast cancer
  • Complementary and alternative therapy
  • Diet
  • Prognosis
  • Prospective cohort study
  • Quality of life

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kwan, M. L., Ambrosone, C. B., Lee, M. M., Barlow, J., Krathwohl, S. E., Ergas, I. J., ... Kushi, L. H. (2008). The Pathways Study: A prospective study of breast cancer survivorship within Kaiser Permanente Northern California. Cancer Causes and Control, 19(10), 1065-1076. https://doi.org/10.1007/s10552-008-9170-5

The Pathways Study : A prospective study of breast cancer survivorship within Kaiser Permanente Northern California. / Kwan, Marilyn L.; Ambrosone, Christine B.; Lee, Marion M.; Barlow, Janice; Krathwohl, Sarah E.; Ergas, Isaac Joshua; Ashley, Christine H.; Bittner, Julie R.; Darbinian, Jeanne; Stronach, Keren; Caan, Bette J.; Davis, Warren; Kutner, Susan E.; Quesenberry, Charles P.; Somkin, Carol P.; Sternfeld, Barbara; Wiencke, John K.; Zheng, Shichun; Kushi, Lawrence H.

In: Cancer Causes and Control, Vol. 19, No. 10, 12.2008, p. 1065-1076.

Research output: Contribution to journalArticle

Kwan, ML, Ambrosone, CB, Lee, MM, Barlow, J, Krathwohl, SE, Ergas, IJ, Ashley, CH, Bittner, JR, Darbinian, J, Stronach, K, Caan, BJ, Davis, W, Kutner, SE, Quesenberry, CP, Somkin, CP, Sternfeld, B, Wiencke, JK, Zheng, S & Kushi, LH 2008, 'The Pathways Study: A prospective study of breast cancer survivorship within Kaiser Permanente Northern California', Cancer Causes and Control, vol. 19, no. 10, pp. 1065-1076. https://doi.org/10.1007/s10552-008-9170-5
Kwan, Marilyn L. ; Ambrosone, Christine B. ; Lee, Marion M. ; Barlow, Janice ; Krathwohl, Sarah E. ; Ergas, Isaac Joshua ; Ashley, Christine H. ; Bittner, Julie R. ; Darbinian, Jeanne ; Stronach, Keren ; Caan, Bette J. ; Davis, Warren ; Kutner, Susan E. ; Quesenberry, Charles P. ; Somkin, Carol P. ; Sternfeld, Barbara ; Wiencke, John K. ; Zheng, Shichun ; Kushi, Lawrence H. / The Pathways Study : A prospective study of breast cancer survivorship within Kaiser Permanente Northern California. In: Cancer Causes and Control. 2008 ; Vol. 19, No. 10. pp. 1065-1076.
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AU - Barlow, Janice

AU - Krathwohl, Sarah E.

AU - Ergas, Isaac Joshua

AU - Ashley, Christine H.

AU - Bittner, Julie R.

AU - Darbinian, Jeanne

AU - Stronach, Keren

AU - Caan, Bette J.

AU - Davis, Warren

AU - Kutner, Susan E.

AU - Quesenberry, Charles P.

AU - Somkin, Carol P.

AU - Sternfeld, Barbara

AU - Wiencke, John K.

AU - Zheng, Shichun

AU - Kushi, Lawrence H.

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KW - Diet

KW - Prognosis

KW - Prospective cohort study

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