The pathology of EMT in mouse mammary tumorigenesis

Robert Cardiff

doi:10.1007/s10911-010-9184-y

The pathology of EMT in mouse mammary tumorigenesis

Robert Cardiff

School of Veterinary Medicine

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective leading to the current status in the context of some of the key molecular biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer.

Original language	English (US)
Pages (from-to)	225-233
Number of pages	9
Journal	Journal of Mammary Gland Biology and Neoplasia
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/s10911-010-9184-y
State	Published - Jun 1 2010

Keywords

E-Cadherin
Epithelial-mesenchymal-transition
Genetically engineered mice
Heterogeneity
Invasion
Metastasis
Mouse mammary tumors
Pathology
Snail
Spindle cell phenotype

ASJC Scopus subject areas

Cancer Research
Oncology
Medicine(all)

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KW - Snail

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