The pathology of EMT in mouse mammary tumorigenesis

Research output: Contribution to journalReview article

45 Scopus citations

Abstract

Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective leading to the current status in the context of some of the key molecular biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer.

Original languageEnglish (US)
Pages (from-to)225-233
Number of pages9
JournalJournal of Mammary Gland Biology and Neoplasia
Volume15
Issue number2
DOIs
StatePublished - Jun 1 2010

Keywords

  • E-Cadherin
  • Epithelial-mesenchymal-transition
  • Genetically engineered mice
  • Heterogeneity
  • Invasion
  • Metastasis
  • Mouse mammary tumors
  • Pathology
  • Snail
  • Spindle cell phenotype

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Fingerprint Dive into the research topics of 'The pathology of EMT in mouse mammary tumorigenesis'. Together they form a unique fingerprint.

  • Cite this