The pathology of EMT in mouse mammary tumorigenesis

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective leading to the current status in the context of some of the key molecular biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer.

Original languageEnglish (US)
Pages (from-to)225-233
Number of pages9
JournalJournal of Mammary Gland Biology and Neoplasia
Volume15
Issue number2
DOIs
StatePublished - Jun 1 2010

Fingerprint

Epithelial-Mesenchymal Transition
Carcinogenesis
Breast
Pathology
Carcinosarcoma
Tissue Transplantation
Human Mammary Glands
Artifacts
Molecular Biology
Neoplasms
Breast Neoplasms

Keywords

  • E-Cadherin
  • Epithelial-mesenchymal-transition
  • Genetically engineered mice
  • Heterogeneity
  • Invasion
  • Metastasis
  • Mouse mammary tumors
  • Pathology
  • Snail
  • Spindle cell phenotype

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

The pathology of EMT in mouse mammary tumorigenesis. / Cardiff, Robert.

In: Journal of Mammary Gland Biology and Neoplasia, Vol. 15, No. 2, 01.06.2010, p. 225-233.

Research output: Contribution to journalReview article

@article{f4f8b135f42644669b4fc534cc6e824d,
title = "The pathology of EMT in mouse mammary tumorigenesis",
abstract = "Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective leading to the current status in the context of some of the key molecular biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer.",
keywords = "E-Cadherin, Epithelial-mesenchymal-transition, Genetically engineered mice, Heterogeneity, Invasion, Metastasis, Mouse mammary tumors, Pathology, Snail, Spindle cell phenotype",
author = "Robert Cardiff",
year = "2010",
month = "6",
day = "1",
doi = "10.1007/s10911-010-9184-y",
language = "English (US)",
volume = "15",
pages = "225--233",
journal = "Journal of Mammary Gland Biology and Neoplasia",
issn = "1083-3021",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - The pathology of EMT in mouse mammary tumorigenesis

AU - Cardiff, Robert

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective leading to the current status in the context of some of the key molecular biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer.

AB - Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective leading to the current status in the context of some of the key molecular biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer.

KW - E-Cadherin

KW - Epithelial-mesenchymal-transition

KW - Genetically engineered mice

KW - Heterogeneity

KW - Invasion

KW - Metastasis

KW - Mouse mammary tumors

KW - Pathology

KW - Snail

KW - Spindle cell phenotype

UR - http://www.scopus.com/inward/record.url?scp=77954860408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954860408&partnerID=8YFLogxK

U2 - 10.1007/s10911-010-9184-y

DO - 10.1007/s10911-010-9184-y

M3 - Review article

C2 - 20521088

AN - SCOPUS:77954860408

VL - 15

SP - 225

EP - 233

JO - Journal of Mammary Gland Biology and Neoplasia

JF - Journal of Mammary Gland Biology and Neoplasia

SN - 1083-3021

IS - 2

ER -