Abstract
Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective leading to the current status in the context of some of the key molecular biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 225-233 |
| Number of pages | 9 |
| Journal | Journal of Mammary Gland Biology and Neoplasia |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 2010 |
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Keywords
- E-Cadherin
- Epithelial-mesenchymal-transition
- Genetically engineered mice
- Heterogeneity
- Invasion
- Metastasis
- Mouse mammary tumors
- Pathology
- Snail
- Spindle cell phenotype
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Medicine(all)
Cite this
The pathology of EMT in mouse mammary tumorigenesis. / Cardiff, Robert.
In: Journal of Mammary Gland Biology and Neoplasia, Vol. 15, No. 2, 01.06.2010, p. 225-233.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The pathology of EMT in mouse mammary tumorigenesis
AU - Cardiff, Robert
PY - 2010/6/1
Y1 - 2010/6/1
N2 - Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective leading to the current status in the context of some of the key molecular biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer.
AB - Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective leading to the current status in the context of some of the key molecular biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer.
KW - E-Cadherin
KW - Epithelial-mesenchymal-transition
KW - Genetically engineered mice
KW - Heterogeneity
KW - Invasion
KW - Metastasis
KW - Mouse mammary tumors
KW - Pathology
KW - Snail
KW - Spindle cell phenotype
UR - http://www.scopus.com/inward/record.url?scp=77954860408&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954860408&partnerID=8YFLogxK
U2 - 10.1007/s10911-010-9184-y
DO - 10.1007/s10911-010-9184-y
M3 - Review article
C2 - 20521088
AN - SCOPUS:77954860408
VL - 15
SP - 225
EP - 233
JO - Journal of Mammary Gland Biology and Neoplasia
JF - Journal of Mammary Gland Biology and Neoplasia
SN - 1083-3021
IS - 2
ER -