The pathogenesis of oligoarticular/polyarticular vs systemic juvenile idiopathic arthritis

Yu Tsan Lin, Chen Ti Wang, M. Eric Gershwin, Bor Luen Chiang

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Juvenile idiopathic arthritis (JIA) has had a long and difficult problem with classification. It is clearly a heterogeneous and multi-factorial autoimmune disease but all too often the distinctions among subtypes were unclear. In fact, there is now increasing evidence of a distinct pathogenesis of oligo/polyarticular JIA compared to systemic JIA. Oligo/polyarticular JIA is an antigen-driven lymphocyte-mediated autoimmune disease with abnormality in the adaptive immune system. Cartilage-derived auto-antigens activate autoreactive T cells including Th1 and Th17 cells with production of pro-inflammatory cytokines IFN-γ and IL-17. On the other hand, the inhibition of regulatory T (Treg) cells including natural Foxp3+ Treg and self-heat shock protein-induced Treg cells with decreased anti-inflammatory cytokine IL-10 results in the loss of immune tolerance. Imbalance between autoreactive Th1/Th17 and Treg cells leads to the failure of T cell tolerance to self-antigens, which contributes to the synovial inflammation of oligo/polyarticular JIA. By contrast, systemic JIA is an autoinflammatory disease with abnormality in the innate immune system. A loss of control of the alternative secretory pathway leading to aberrant activation of phagocytes including monocytes, macrophages and neutrophils seems to be involved in the release of pro-inflammatory cytokines IL-1, IL-6, IL-18 and pro-inflammatory S100-proteins, which contribute to the multisystem inflammation of systemic JIA. Markedly distinct pathogenesis of oligo/polyarticular JIA and systemic JIA implies that they might need different treatment strategies.

Original languageEnglish (US)
Pages (from-to)482-489
Number of pages8
JournalAutoimmunity Reviews
Volume10
Issue number8
DOIs
StatePublished - Jun 2011

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Juvenile Arthritis
Regulatory T-Lymphocytes
Th17 Cells
Th1 Cells
Cytokines
Autoimmune Diseases
Immune System
Inflammation
T-Lymphocytes
Antigens
Immune Tolerance
Interleukin-18
Interleukin-17
S100 Proteins
Secretory Pathway
Autoantigens
Phagocytes
Heat-Shock Proteins
Interleukin-1
Interleukin-10

Keywords

  • Autoinflammatory disease
  • Oligo/polyarticular juvenile idiopathic arthritis
  • Phagocytes
  • Regulatory T cells
  • Systemic juvenile idiopathic arthritis
  • Th17 cells

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The pathogenesis of oligoarticular/polyarticular vs systemic juvenile idiopathic arthritis. / Lin, Yu Tsan; Wang, Chen Ti; Gershwin, M. Eric; Chiang, Bor Luen.

In: Autoimmunity Reviews, Vol. 10, No. 8, 06.2011, p. 482-489.

Research output: Contribution to journalArticle

Lin, Yu Tsan ; Wang, Chen Ti ; Gershwin, M. Eric ; Chiang, Bor Luen. / The pathogenesis of oligoarticular/polyarticular vs systemic juvenile idiopathic arthritis. In: Autoimmunity Reviews. 2011 ; Vol. 10, No. 8. pp. 482-489.
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