The pathogenesis of hexachlorophene neuropathy

in vivo and in vitro studies

David E Pleasure, J. Towfighi, D. Silberberg, J. Parris

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In rats fed hexachlorophene (HCP), hindlimb weakness developed within 2 to 3 wk and sciatic nerves showed widespread myelin intraperiod line splitting, intramyelinic vacuolization and occasional segmental demyelination. Myelin was prepared from the nerves of the hexachlorophene treated rats; in comparison to controls, the myelin yield was reduced by about 40%. Hexachlorophene also caused myelin disruption in vitro; when rat cerebellum tissue cultures were exposed to hexachlorophene, myelinic blebs appeared within 12 hr. When chick embryo sciatic nerves were incubated with [14C]HCP, the hexachlorophene was rapidly bound to the nerves; binding was solely by hydrophobic interaction and was not myelin specific. After a latent period of 1 hr hexachlorophene caused a profound inhibition of protein and lipid synthesis by the chick nerves. During incubation with hexachlorophene, nerve content of adenosine triphosphate fell, with consequent diminution in the rate of activation of sulfate to 3' phosphoadenosine 5' phosphosulfate.

Original languageEnglish (US)
Pages (from-to)1068-1075
Number of pages8
JournalNeurology
Volume24
Issue number11
StatePublished - 1974
Externally publishedYes

Fingerprint

Hexachlorophene
Myelin Sheath
Sciatic Nerve
Phosphoadenosine Phosphosulfate
In Vitro Techniques
Demyelinating Diseases
Chick Embryo
Blister
Hindlimb
Hydrophobic and Hydrophilic Interactions
Cerebellum
Sulfates
Adenosine Triphosphate
Lipids

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Pleasure, D. E., Towfighi, J., Silberberg, D., & Parris, J. (1974). The pathogenesis of hexachlorophene neuropathy: in vivo and in vitro studies. Neurology, 24(11), 1068-1075.

The pathogenesis of hexachlorophene neuropathy : in vivo and in vitro studies. / Pleasure, David E; Towfighi, J.; Silberberg, D.; Parris, J.

In: Neurology, Vol. 24, No. 11, 1974, p. 1068-1075.

Research output: Contribution to journalArticle

Pleasure, DE, Towfighi, J, Silberberg, D & Parris, J 1974, 'The pathogenesis of hexachlorophene neuropathy: in vivo and in vitro studies', Neurology, vol. 24, no. 11, pp. 1068-1075.
Pleasure DE, Towfighi J, Silberberg D, Parris J. The pathogenesis of hexachlorophene neuropathy: in vivo and in vitro studies. Neurology. 1974;24(11):1068-1075.
Pleasure, David E ; Towfighi, J. ; Silberberg, D. ; Parris, J. / The pathogenesis of hexachlorophene neuropathy : in vivo and in vitro studies. In: Neurology. 1974 ; Vol. 24, No. 11. pp. 1068-1075.
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