The p53 family: Same response, different signals?

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

TP53, the gene that encodes p53, is a well-defined tumor suppressor gene that is frequently mutated in human cancers. Recently, two proteins homologous to p53, termed p73 and p63, were identified. Current data indicate that both p73 and p63, like p53, can induce cell-cycle arrest and apoptosis, suggesting that they might also be tumor suppressors. However, the physiological signals that can regulate p53, for example, DNA damage, have no effect on p73, as tested in several cell lines. Furthermore, the signaling pathways by which p73 (and possibly p63) induces cell-cycle arrest and apoptosis appear to be similar to those of p53, but also have important differences. Thus, the p53 family proteins are closely related but might have distinct physiological functions.

Original languageEnglish (US)
Pages (from-to)387-392
Number of pages6
JournalMolecular Medicine Today
Volume5
Issue number9
DOIs
StatePublished - Sep 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine

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