The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis

Annarosa Floreani, Raffaella Motta, Nora Cazzagon, Irene Franceschet, Massimo Roncalli, Teresa Del Ross, Floriano Rosina, Ana Lleo, Claudia Mescoli, Guido Colloredo, Pietro Invernizzi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis is an extremely rare condition that has been reported in only six published cases so far. Methods: Here we report two cases showing the clinical manifestations of both primary biliary cirrhosis and primary sclerosing cholangitis. Results: In one case the overlap condition was associated with psoriatric arthritis, and the patient successfully underwent dual treatment with ursodeoxycholic acid and the anti-tumour necrosis factor-alpha agent adalimumab. In the second case, the predominant condition was, initially, an antimitochondrial antibody-negative primary biliary cirrhosis with progressive course towards end-stage liver disease; the patient then developed either antimitochondrial antibody positivity or changes in the biliary tree compatible with primary sclerosing cholangitis. Conclusions: These two cases add information on a controversial issue in the literature, and indicate the importance of recognizing a possible overlap syndrome to optimize treatment.

Original languageEnglish (US)
Pages (from-to)432-435
Number of pages4
JournalDigestive and Liver Disease
Volume47
Issue number5
DOIs
StatePublished - May 1 2015
Externally publishedYes

Fingerprint

Sclerosing Cholangitis
Biliary Liver Cirrhosis
Ursodeoxycholic Acid
End Stage Liver Disease
Antibodies
Biliary Tract
Arthritis
Tumor Necrosis Factor-alpha
Therapeutics

Keywords

  • Overlap syndrome
  • Primary biliary cirrhosis
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Floreani, A., Motta, R., Cazzagon, N., Franceschet, I., Roncalli, M., Del Ross, T., ... Invernizzi, P. (2015). The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis. Digestive and Liver Disease, 47(5), 432-435. https://doi.org/10.1016/j.dld.2015.02.002

The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis. / Floreani, Annarosa; Motta, Raffaella; Cazzagon, Nora; Franceschet, Irene; Roncalli, Massimo; Del Ross, Teresa; Rosina, Floriano; Lleo, Ana; Mescoli, Claudia; Colloredo, Guido; Invernizzi, Pietro.

In: Digestive and Liver Disease, Vol. 47, No. 5, 01.05.2015, p. 432-435.

Research output: Contribution to journalArticle

Floreani, A, Motta, R, Cazzagon, N, Franceschet, I, Roncalli, M, Del Ross, T, Rosina, F, Lleo, A, Mescoli, C, Colloredo, G & Invernizzi, P 2015, 'The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis', Digestive and Liver Disease, vol. 47, no. 5, pp. 432-435. https://doi.org/10.1016/j.dld.2015.02.002
Floreani A, Motta R, Cazzagon N, Franceschet I, Roncalli M, Del Ross T et al. The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis. Digestive and Liver Disease. 2015 May 1;47(5):432-435. https://doi.org/10.1016/j.dld.2015.02.002
Floreani, Annarosa ; Motta, Raffaella ; Cazzagon, Nora ; Franceschet, Irene ; Roncalli, Massimo ; Del Ross, Teresa ; Rosina, Floriano ; Lleo, Ana ; Mescoli, Claudia ; Colloredo, Guido ; Invernizzi, Pietro. / The overlap syndrome between primary biliary cirrhosis and primary sclerosing cholangitis. In: Digestive and Liver Disease. 2015 ; Vol. 47, No. 5. pp. 432-435.
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