The opiate antagonist naloxone does not consistently block inhibition of spinal nociceptive transmission produced by stimulation in lateral midbrain reticular formation of the cat

Earl Carstens; M. Zimmermann

doi:10.1016/0304-3940(80)90170-6

The opiate antagonist naloxone does not consistently block inhibition of spinal nociceptive transmission produced by stimulation in lateral midbrain reticular formation of the cat

Earl Carstens, M. Zimmermann

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Electrical stimulation in the lateral midbrain reticular formation (LRF) inhibited the responses of spinal dorsal horn neurons to noxious (50°C) skin heating. Systemic administration of naloxone (0.1-2 mg/kg) had no effect on inhibition produced by LRF stimulation in 10 units, while this inhibition was partially blocked in 3 units. The results indicate that endogenous opiates are not primarily involved in mediating descending inhibition from LRF stimulation.

Original language	English (US)
Pages (from-to)	335-339
Number of pages	5
Journal	Neuroscience Letters
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(80)90170-6
State	Published - 1980
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/0304-3940(80)90170-6

Cite this

@article{7171c2e6ed9548e19a7fc17f286c67df,

title = "The opiate antagonist naloxone does not consistently block inhibition of spinal nociceptive transmission produced by stimulation in lateral midbrain reticular formation of the cat",

abstract = "Electrical stimulation in the lateral midbrain reticular formation (LRF) inhibited the responses of spinal dorsal horn neurons to noxious (50°C) skin heating. Systemic administration of naloxone (0.1-2 mg/kg) had no effect on inhibition produced by LRF stimulation in 10 units, while this inhibition was partially blocked in 3 units. The results indicate that endogenous opiates are not primarily involved in mediating descending inhibition from LRF stimulation.",

author = "Earl Carstens and M. Zimmermann",

year = "1980",

doi = "10.1016/0304-3940(80)90170-6",

language = "English (US)",

volume = "20",

pages = "335--339",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - The opiate antagonist naloxone does not consistently block inhibition of spinal nociceptive transmission produced by stimulation in lateral midbrain reticular formation of the cat

AU - Carstens, Earl

AU - Zimmermann, M.

PY - 1980

Y1 - 1980

N2 - Electrical stimulation in the lateral midbrain reticular formation (LRF) inhibited the responses of spinal dorsal horn neurons to noxious (50°C) skin heating. Systemic administration of naloxone (0.1-2 mg/kg) had no effect on inhibition produced by LRF stimulation in 10 units, while this inhibition was partially blocked in 3 units. The results indicate that endogenous opiates are not primarily involved in mediating descending inhibition from LRF stimulation.

AB - Electrical stimulation in the lateral midbrain reticular formation (LRF) inhibited the responses of spinal dorsal horn neurons to noxious (50°C) skin heating. Systemic administration of naloxone (0.1-2 mg/kg) had no effect on inhibition produced by LRF stimulation in 10 units, while this inhibition was partially blocked in 3 units. The results indicate that endogenous opiates are not primarily involved in mediating descending inhibition from LRF stimulation.

UR - http://www.scopus.com/inward/record.url?scp=0019288878&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019288878&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(80)90170-6

DO - 10.1016/0304-3940(80)90170-6

M3 - Article

C2 - 7443080

AN - SCOPUS:0019288878

VL - 20

SP - 335

EP - 339

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 3

ER -

The opiate antagonist naloxone does not consistently block inhibition of spinal nociceptive transmission produced by stimulation in lateral midbrain reticular formation of the cat

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this