The opiate antagonist naloxone does not consistently block inhibition of spinal nociceptive transmission produced by stimulation in lateral midbrain reticular formation of the cat

Earl Carstens, M. Zimmermann

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Electrical stimulation in the lateral midbrain reticular formation (LRF) inhibited the responses of spinal dorsal horn neurons to noxious (50°C) skin heating. Systemic administration of naloxone (0.1-2 mg/kg) had no effect on inhibition produced by LRF stimulation in 10 units, while this inhibition was partially blocked in 3 units. The results indicate that endogenous opiates are not primarily involved in mediating descending inhibition from LRF stimulation.

Original languageEnglish (US)
Pages (from-to)335-339
Number of pages5
JournalNeuroscience Letters
Volume20
Issue number3
DOIs
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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