Abstract
Electrical stimulation in the lateral midbrain reticular formation (LRF) inhibited the responses of spinal dorsal horn neurons to noxious (50°C) skin heating. Systemic administration of naloxone (0.1-2 mg/kg) had no effect on inhibition produced by LRF stimulation in 10 units, while this inhibition was partially blocked in 3 units. The results indicate that endogenous opiates are not primarily involved in mediating descending inhibition from LRF stimulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 335-339 |
| Number of pages | 5 |
| Journal | Neuroscience Letters |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1980 |
| Externally published | Yes |
ASJC Scopus subject areas
- Neuroscience(all)
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Carstens, E., & Zimmermann, M. (1980). The opiate antagonist naloxone does not consistently block inhibition of spinal nociceptive transmission produced by stimulation in lateral midbrain reticular formation of the cat. Neuroscience Letters, 20(3), 335-339. https://doi.org/10.1016/0304-3940(80)90170-6