Abstract
Discharges were recorded from spinal dorsal horn neurons in response to noxious skin heating (e.g. 50°C). Repetitive electrical stimulation of the mesencephalic periaqueductal gray (PAG) inhibited these nociceptive discharges. In each of 9 experiments systemic administration of naloxone (1-3 mg/kg) did not affect this descending inhibition, arguing against involvement of endogenous opiates.
Original language | English (US) |
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Pages (from-to) | 323-327 |
Number of pages | 5 |
Journal | Neuroscience Letters |
Volume | 11 |
Issue number | 3 |
DOIs | |
State | Published - 1979 |
Externally published | Yes |
ASJC Scopus subject areas
- Neuroscience(all)