Abstract
Discharges were recorded from spinal dorsal horn neurons in response to noxious skin heating (e.g. 50°C). Repetitive electrical stimulation of the mesencephalic periaqueductal gray (PAG) inhibited these nociceptive discharges. In each of 9 experiments systemic administration of naloxone (1-3 mg/kg) did not affect this descending inhibition, arguing against involvement of endogenous opiates.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 323-327 |
| Number of pages | 5 |
| Journal | Neuroscience Letters |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1979 |
| Externally published | Yes |
ASJC Scopus subject areas
- Neuroscience(all)
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Carstens, E., Klumpp, D., & Zimmermann, M. (1979). The opiate antagonist, naloxone, does not affect descending inhibition from midbrain of nociceptive spinal neuronal discharges in the cat. Neuroscience Letters, 11(3), 323-327. https://doi.org/10.1016/0304-3940(79)90016-8