The opiate antagonist, naloxone, does not affect descending inhibition from midbrain of nociceptive spinal neuronal discharges in the cat

Earl Carstens; D. Klumpp; M. Zimmermann

doi:10.1016/0304-3940(79)90016-8

The opiate antagonist, naloxone, does not affect descending inhibition from midbrain of nociceptive spinal neuronal discharges in the cat

Earl Carstens, D. Klumpp, M. Zimmermann

Research output: Contribution to journal › Article

27 Scopus citations

Abstract

Discharges were recorded from spinal dorsal horn neurons in response to noxious skin heating (e.g. 50°C). Repetitive electrical stimulation of the mesencephalic periaqueductal gray (PAG) inhibited these nociceptive discharges. In each of 9 experiments systemic administration of naloxone (1-3 mg/kg) did not affect this descending inhibition, arguing against involvement of endogenous opiates.

Original language	English (US)
Pages (from-to)	323-327
Number of pages	5
Journal	Neuroscience Letters
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(79)90016-8
State	Published - 1979
Externally published	Yes

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Neuroscience(all)

Cite this

Carstens, E., Klumpp, D., & Zimmermann, M. (1979). The opiate antagonist, naloxone, does not affect descending inhibition from midbrain of nociceptive spinal neuronal discharges in the cat. Neuroscience Letters, 11(3), 323-327. https://doi.org/10.1016/0304-3940(79)90016-8

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10.1016/0304-3940(79)90016-8