The opiate antagonist, naloxone, does not affect descending inhibition from midbrain of nociceptive spinal neuronal discharges in the cat

Earl Carstens, D. Klumpp, M. Zimmermann

Research output: Contribution to journalArticle

27 Scopus citations


Discharges were recorded from spinal dorsal horn neurons in response to noxious skin heating (e.g. 50°C). Repetitive electrical stimulation of the mesencephalic periaqueductal gray (PAG) inhibited these nociceptive discharges. In each of 9 experiments systemic administration of naloxone (1-3 mg/kg) did not affect this descending inhibition, arguing against involvement of endogenous opiates.

Original languageEnglish (US)
Pages (from-to)323-327
Number of pages5
JournalNeuroscience Letters
Issue number3
StatePublished - 1979
Externally publishedYes


ASJC Scopus subject areas

  • Neuroscience(all)

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