The operation of pattern separation and pattern completion processes associated with different attributes or domains of memory

Michael R. Hunsaker, Raymond P. Kesner

Research output: Contribution to journalArticle

129 Scopus citations

Abstract

Pattern separation and pattern completion processes are central to how the brain processes information in an efficient manner. Research into these processes is escalating and deficient pattern separation is being implicated in a wide array of genetic disorders as well as in neurocognitive aging. Despite the quantity of research, there remains a controversy as to precisely which behavioral paradigms should be used to best tap into pattern separation and pattern completion processes, as well as to what constitute legitimate outcome measures reflecting impairments in pattern separation and pattern completion. This review will discuss a theory based on multiple memory systems that provides a framework upon which behavioral tasks can be designed and their results interpreted. Furthermore, this review will discuss the nature of pattern separation and pattern completion and extend these processes outside the hippocampus and across all domains of information processing. After these discussions, an optimal strategy for designing behavioral paradigms to evaluate pattern separation and pattern completion processes will be provided.

Original languageEnglish (US)
Pages (from-to)36-58
Number of pages23
JournalNeuroscience and Biobehavioral Reviews
Volume37
Issue number1
DOIs
StatePublished - Jan 2013

Keywords

  • Affect
  • Attributes
  • Computational model
  • Pattern completion
  • Pattern separation
  • Response
  • Sensory/perceptual
  • Spatial
  • Temporal

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Neuropsychology and Physiological Psychology

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