The ontogeny and phylogenetic conservation of MAP 2 forms

Richard P Tucker, C. Viereck, A. I. Matus

Research output: Contribution to journalArticle

Abstract

In the adult rat brain, MAP 2 is a high-molecular weight protein that is highly concentrated in dendrites. Immunoblots of homogenates of developing rat brain have indicated that a low-molecular weight form of MAP 2, MAP 2 c, is transiently expressed as the brain is undergoing morphogenesis. Using MAP 2-specific monoclonal antibodies, we have demonstrated that the compartmentalization of high-molecular weight MAP 2 and the developmental regulation of MAP 2 are conserved in mammalian, avian, and amphibian brain. We have also determined the distribution of MAP 2 c in developing neuronal tissue. MAP 2 c appears before high-molecular weight MAP 2 in developing neurons, and in contrast to the dendrite-specific high-molecular weight forms of MAP 2, MAP 2 c is present in axons and glia. We have also shown that MAP 2 c is present in the adult rat retina, where it is concentrated in regenerative photosensitive cells. The transient expression of MAP 2 c in the developing brain of three species as well as in adult photosensitive cells suggests a role for this protein in neurite growth and plasticity.

Original languageEnglish (US)
Pages (from-to)195-199
Number of pages5
JournalProtoplasma
Volume145
Issue number2-3
DOIs
StatePublished - Jun 1988
Externally publishedYes

Fingerprint

ontogeny
Molecular Weight
molecular weight
brain
phylogeny
Brain
dendrites
Dendrites
rats
neurites
Amphibians
Neurites
Morphogenesis
retina
axons
Neuroglia
morphogenesis
Axons
Retina
amphibians

Keywords

  • Development
  • Microtubule-associated proteins
  • Quail
  • Rat
  • Xenopus laevis

ASJC Scopus subject areas

  • Cell Biology
  • Plant Science

Cite this

The ontogeny and phylogenetic conservation of MAP 2 forms. / Tucker, Richard P; Viereck, C.; Matus, A. I.

In: Protoplasma, Vol. 145, No. 2-3, 06.1988, p. 195-199.

Research output: Contribution to journalArticle

Tucker, Richard P ; Viereck, C. ; Matus, A. I. / The ontogeny and phylogenetic conservation of MAP 2 forms. In: Protoplasma. 1988 ; Vol. 145, No. 2-3. pp. 195-199.
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