The oncologic safety of breast fat grafting and contradictions between basic science and clinical studies: A systematic review of the recent literature

Heath J. Charvet, Hakan Orbay, Michael S Wong, David E Sahar

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Fat grafting is increasingly popular and is becoming a common practice in plastic surgery for postmastectomy breast reconstruction and aesthetic breast augmentation; however, concerns over the oncologic safety remains a controversial and hot topic among scientists and surgeons. Basic science and laboratory research repeatedly show a potentially dangerous effect of adipose-derived stem cells on breast cancer cells; however, clinical research, although limited, continually fails to show an increase in breast cancer recurrence after breast fat grafting, with the exception of 1 small study on a subset patient population with intraepithelial neoplasm of the breast. The aim of this review is to summarize the recent conflicting basic science and clinical data to better understand the safety of breast fat grafting from an oncological perspective.

Original languageEnglish (US)
Pages (from-to)471-479
Number of pages9
JournalAnnals of Plastic Surgery
Volume75
Issue number4
DOIs
StatePublished - Oct 1 2015

Fingerprint

Breast
Fats
Safety
Breast Neoplasms
Mammaplasty
Carcinoma in Situ
Plastic Surgery
Esthetics
Research
Stem Cells
Recurrence
Clinical Studies
Population

Keywords

  • Adipose-derived stem cells
  • Breast cancer
  • Fat grafting
  • Mesenchymal stem cells

ASJC Scopus subject areas

  • Surgery

Cite this

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