The odyssey on MeCP2 and parental imprinting

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

DNA methylation in mammals has long been implicated in the epigenetic mechanism of parental imprinting, in which selective expression of one allele of specific genes is based on parental origin. Methyl CpG binding protein 2 (MeCP2) selectively binds to methylated DNA and mutations in the MECP2 cause the autism-spectrum neurodevelopmental disorder Rett syndrome. This review outlines the emerging story of how MeCP2 has been implicated in the regulation of specific imprinted genes and loci, including 'UBE3A and DLX5. The story of MeCP2 and parental imprinting has unfolded with some interesting but unexpected twists, revealing new insights on the function of MeCP2 in the process.

Original languageEnglish (US)
Pages (from-to)5-10
Number of pages6
JournalEpigenetics
Volume2
Issue number1
StatePublished - Jan 2007

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Methyl-CpG-Binding Protein 2
Genomic Imprinting
Rett Syndrome
DNA Methylation
Epigenomics
Genes
Mammals
Alleles
Mutation
DNA

Keywords

  • DNA methylation
  • Epigenetic
  • Methyl CpG binding protein
  • Neurodevelopment
  • Parental imprinting

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Medicine(all)

Cite this

The odyssey on MeCP2 and parental imprinting. / LaSalle, Janine M.

In: Epigenetics, Vol. 2, No. 1, 01.2007, p. 5-10.

Research output: Contribution to journalArticle

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