The Ocular Hypertension Treatment Study: Baseline factors that predict the onset of primary open-angle glaucoma

Mae O. Gordon, Julia A. Beiser, James D Brandt, Dale K. Heuer, Eve J. Higginbotham, Chris A. Johnson, John L Keltner, J. Philip Miller, Richard K. Parrish, M. Roy Wilson, Michael A. Kass

Research output: Contribution to journalArticle

1720 Citations (Scopus)

Abstract

Background: The Ocular Hypertension Treatment Study (OHTS) has shown that topical ocular hypotensive medication is effective in delaying or preventing the onset of primary open-angle glaucoma (POAG) in individuals with elevated intraocular pressure (ocular hypertension) and no evidence of glaucomatous damage. Objective: To describe baseline demographic and clinical factors that predict which participants in the OHTS developed POAG. Methods: Baseline demographic and clinical data were collected prior to randomization except for corneal thickness measurements, which were performed during follow-up. Proportional hazards models were used to identify factors that predicted which participants in the OHTS developed POAG. Results: In univariate analyses, baseline factors that predicted the development of POAG included older age, race (African American), sex (male), larger vertical cup-disc ratio, larger horizontal cup-disc ratio, higher intraocular pressure, greater Humphrey visual field pattern standard deviation, heart disease, and thinner central corneal measurement. In multivariate analyses, baseline factors that predicted the development of POAG included older age, larger vertical or horizontal cup-disc ratio, higher intraocular pressure, greater pattern standard deviation, and thinner central corneal measurement. Conclusions: Baseline age, vertical and horizontal cup-disc ratio, pattern standard deviation, and intraocular pressure were good predictors for the onset of POAG in the OHTS. Central corneal thickness was found to be a powerful predictor for the development of POAG.

Original languageEnglish (US)
Pages (from-to)714-720
Number of pages7
JournalArchives of Ophthalmology
Volume120
Issue number6
StatePublished - 2002

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Ocular Hypertension
Intraocular Pressure
Therapeutics
Corneal Pachymetry
Demography
Random Allocation
Primary Open Angle Glaucoma
Visual Fields
Proportional Hazards Models
African Americans
Statistical Factor Analysis
Heart Diseases
Multivariate Analysis

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Gordon, M. O., Beiser, J. A., Brandt, J. D., Heuer, D. K., Higginbotham, E. J., Johnson, C. A., ... Kass, M. A. (2002). The Ocular Hypertension Treatment Study: Baseline factors that predict the onset of primary open-angle glaucoma. Archives of Ophthalmology, 120(6), 714-720.

The Ocular Hypertension Treatment Study : Baseline factors that predict the onset of primary open-angle glaucoma. / Gordon, Mae O.; Beiser, Julia A.; Brandt, James D; Heuer, Dale K.; Higginbotham, Eve J.; Johnson, Chris A.; Keltner, John L; Philip Miller, J.; Parrish, Richard K.; Roy Wilson, M.; Kass, Michael A.

In: Archives of Ophthalmology, Vol. 120, No. 6, 2002, p. 714-720.

Research output: Contribution to journalArticle

Gordon, MO, Beiser, JA, Brandt, JD, Heuer, DK, Higginbotham, EJ, Johnson, CA, Keltner, JL, Philip Miller, J, Parrish, RK, Roy Wilson, M & Kass, MA 2002, 'The Ocular Hypertension Treatment Study: Baseline factors that predict the onset of primary open-angle glaucoma', Archives of Ophthalmology, vol. 120, no. 6, pp. 714-720.
Gordon, Mae O. ; Beiser, Julia A. ; Brandt, James D ; Heuer, Dale K. ; Higginbotham, Eve J. ; Johnson, Chris A. ; Keltner, John L ; Philip Miller, J. ; Parrish, Richard K. ; Roy Wilson, M. ; Kass, Michael A. / The Ocular Hypertension Treatment Study : Baseline factors that predict the onset of primary open-angle glaucoma. In: Archives of Ophthalmology. 2002 ; Vol. 120, No. 6. pp. 714-720.
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