Abstract
This chapter reviews and evaluates evidence bearing on the questions of whether and how both early (i.e., pre- and perinatal) and late (i.e., adolescent) neurodevelopmental influences may be involved in the etiology and pathogenesis of Schizophrenia. It describes the various neural disturbances detected in Schizophrenia. This is followed by an analysis of studies investigating the roles of genetic and nongenetic factors in brain abnormalities. These studies provide a framework for hypothesis generation concerning the timing of onset and course of brain abnormalities in Schizophrenia. The chapter presents an analysis of the various literatures bearing more directly on the question of the timing of onset and course of brain abnormalities in Schizophrenia. It finally provides an updated version of the neurodevelopmental hypothesis of Schizophrenia, specifying a number of ways in which particular sets of early and late influences might interact in determining the timing of onset and course of the disorder.
| Original language | English (US) |
|---|---|
| Title of host publication | Risk, Disorder, and Adaptation |
| Publisher | wiley |
| Pages | 542-569 |
| Number of pages | 28 |
| Volume | 3 |
| ISBN (Electronic) | 9780470939406 |
| ISBN (Print) | 9780471237389 |
| DOIs | |
| State | Published - Jan 1 2006 |
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Keywords
- Brain abnormalities in Schizophrenia
- First-episode Schizophrenia
- Genetic regulation of synaptic pruning
- Magnetic resonance spectroscopy studies
- Neurodevelopmental model of Schizophrenia
- Perinatal brain development
- Prenatal stress
- Schizophrenia prodrome
ASJC Scopus subject areas
- Psychology(all)
Cite this
The Neurodevelopmental Model of Schizophrenia : Updated. / Bearden, Carrie E.; Meyer, Stephanie E.; Loewy, Rachel L.; Niendam, Tara A; Cannon, Tyrone D.
Risk, Disorder, and Adaptation. Vol. 3 wiley, 2006. p. 542-569.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - The Neurodevelopmental Model of Schizophrenia
T2 - Updated
AU - Bearden, Carrie E.
AU - Meyer, Stephanie E.
AU - Loewy, Rachel L.
AU - Niendam, Tara A
AU - Cannon, Tyrone D.
PY - 2006/1/1
Y1 - 2006/1/1
N2 - This chapter reviews and evaluates evidence bearing on the questions of whether and how both early (i.e., pre- and perinatal) and late (i.e., adolescent) neurodevelopmental influences may be involved in the etiology and pathogenesis of Schizophrenia. It describes the various neural disturbances detected in Schizophrenia. This is followed by an analysis of studies investigating the roles of genetic and nongenetic factors in brain abnormalities. These studies provide a framework for hypothesis generation concerning the timing of onset and course of brain abnormalities in Schizophrenia. The chapter presents an analysis of the various literatures bearing more directly on the question of the timing of onset and course of brain abnormalities in Schizophrenia. It finally provides an updated version of the neurodevelopmental hypothesis of Schizophrenia, specifying a number of ways in which particular sets of early and late influences might interact in determining the timing of onset and course of the disorder.
AB - This chapter reviews and evaluates evidence bearing on the questions of whether and how both early (i.e., pre- and perinatal) and late (i.e., adolescent) neurodevelopmental influences may be involved in the etiology and pathogenesis of Schizophrenia. It describes the various neural disturbances detected in Schizophrenia. This is followed by an analysis of studies investigating the roles of genetic and nongenetic factors in brain abnormalities. These studies provide a framework for hypothesis generation concerning the timing of onset and course of brain abnormalities in Schizophrenia. The chapter presents an analysis of the various literatures bearing more directly on the question of the timing of onset and course of brain abnormalities in Schizophrenia. It finally provides an updated version of the neurodevelopmental hypothesis of Schizophrenia, specifying a number of ways in which particular sets of early and late influences might interact in determining the timing of onset and course of the disorder.
KW - Brain abnormalities in Schizophrenia
KW - First-episode Schizophrenia
KW - Genetic regulation of synaptic pruning
KW - Magnetic resonance spectroscopy studies
KW - Neurodevelopmental model of Schizophrenia
KW - Perinatal brain development
KW - Prenatal stress
KW - Schizophrenia prodrome
UR - http://www.scopus.com/inward/record.url?scp=84983579899&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84983579899&partnerID=8YFLogxK
U2 - 10.1002/9780470939406.ch14
DO - 10.1002/9780470939406.ch14
M3 - Chapter
AN - SCOPUS:84983579899
SN - 9780471237389
VL - 3
SP - 542
EP - 569
BT - Risk, Disorder, and Adaptation
PB - wiley
ER -