The neurobiology of aging

K. M. Kelly, N. L. Nadon, John Morrison, O. Thibault, C. A. Barnes, E. M. Blalock

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Basic principles of the neurobiology of aging were reviewed within selected topic areas chosen for their potential relevance to epileptogenesis in the aging brain. The availability of National Institute on Aging-supported aged mouse and rat strains and other biological resources for studies of aging and age-associated diseases was presented, and general principles of animal use in gerontological research were discussed. Neurobiological changes during normal brain aging were compared and contrasted with neuropathological events of Alzheimer's disease (AD) and age-associated memory impairment (AAMI). Major themes addressed were the loss of synaptic connections as vulnerable neurons die and circuits deteriorate in AD, the absence of significant neuron loss but potential synaptic alteration in the same circuits in AAMI, and the effects of decreased estrogen on normal aging. The "calcium hypothesis of brain aging" was examined by a review of calcium dyshomeostasis and synaptic communication in aged hippocampus, with particular emphasis on the role of L-type voltage-gated calcium channels during normal aging. Established and potential mechanisms of hippocampal plasticity during aging were discussed, including long-term potentiation, changes in functional connectivity, and increased gap junctions, the latter possibly being related to enhanced network excitability. Lastly, application of microarray gene chip technology to aging brain studies was presented and use of the hippocampal "zipper slice" preparation to study aged neurons was described.

Original languageEnglish (US)
JournalEpilepsy Research
Volume68
Issue numberSUPPL. 1
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

Fingerprint

Neurobiology
Brain
Neurons
Alzheimer Disease
National Institute on Aging (U.S.)
Calcium
Synaptic Potentials
Long-Term Potentiation
Gap Junctions
Calcium Channels
Oligonucleotide Array Sequence Analysis
Hippocampus
Estrogens
Communication
Technology
Research

Keywords

  • Again brain
  • Clinical trials
  • Elderly
  • Epilepsy
  • Geriatric
  • PK

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Kelly, K. M., Nadon, N. L., Morrison, J., Thibault, O., Barnes, C. A., & Blalock, E. M. (2006). The neurobiology of aging. Epilepsy Research, 68(SUPPL. 1). https://doi.org/10.1016/j.eplepsyres.2005.07.015

The neurobiology of aging. / Kelly, K. M.; Nadon, N. L.; Morrison, John; Thibault, O.; Barnes, C. A.; Blalock, E. M.

In: Epilepsy Research, Vol. 68, No. SUPPL. 1, 01.01.2006.

Research output: Contribution to journalArticle

Kelly, KM, Nadon, NL, Morrison, J, Thibault, O, Barnes, CA & Blalock, EM 2006, 'The neurobiology of aging', Epilepsy Research, vol. 68, no. SUPPL. 1. https://doi.org/10.1016/j.eplepsyres.2005.07.015
Kelly KM, Nadon NL, Morrison J, Thibault O, Barnes CA, Blalock EM. The neurobiology of aging. Epilepsy Research. 2006 Jan 1;68(SUPPL. 1). https://doi.org/10.1016/j.eplepsyres.2005.07.015
Kelly, K. M. ; Nadon, N. L. ; Morrison, John ; Thibault, O. ; Barnes, C. A. ; Blalock, E. M. / The neurobiology of aging. In: Epilepsy Research. 2006 ; Vol. 68, No. SUPPL. 1.
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