The Netrin receptor Frazzled is required in the target for establishment of retinal projections in the Drosophila visual system

Qizhi Gong, Radha Rangarajan, Mark Seeger, Ulrike Gaul

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Retinal axons in Drosophila make precise topographic connections with their target cells in the optic lobe. Here we investigate the role of the Netrins and their receptor Frazzled in the establishment of retinal projections. We find that the Netrins, although expressed in the target, are not required for retinal projections. Surprisingly, Frazzled, found on both retinal fibers and target cells, is required in the target for attracting retinal fibers, while playing at best a redundant role in the retinal fibers themselves; this finding demonstrates that target attraction is necessary for topographic map formation. Finally, we show that Frazzled is not required for the differentiation of cells in the target. Our data suggest that Frazzled does not function as a Netrin receptor in attracting retinal fibers to the target; nor does it seem to act as a homotypic cell adhesion molecule. We favor the possibility that Frazzled in the target interacts with a component on the surface of retinal fibers, possibly another Netrin receptor.

Original languageEnglish (US)
Pages (from-to)1451-1456
Number of pages6
JournalDevelopment
Volume126
Issue number7
StatePublished - Apr 1999
Externally publishedYes

Fingerprint

Drosophila
Cell Adhesion Molecules
Axons
Cell Differentiation
netrin receptors

Keywords

  • Drosophila
  • Frazzled
  • Netrin
  • Retinal projection
  • Topographic map formation
  • Visual system development

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology

Cite this

The Netrin receptor Frazzled is required in the target for establishment of retinal projections in the Drosophila visual system. / Gong, Qizhi; Rangarajan, Radha; Seeger, Mark; Gaul, Ulrike.

In: Development, Vol. 126, No. 7, 04.1999, p. 1451-1456.

Research output: Contribution to journalArticle

Gong, Qizhi ; Rangarajan, Radha ; Seeger, Mark ; Gaul, Ulrike. / The Netrin receptor Frazzled is required in the target for establishment of retinal projections in the Drosophila visual system. In: Development. 1999 ; Vol. 126, No. 7. pp. 1451-1456.
@article{695a4b9bcbc84491ac1be1980e6ae82c,
title = "The Netrin receptor Frazzled is required in the target for establishment of retinal projections in the Drosophila visual system",
abstract = "Retinal axons in Drosophila make precise topographic connections with their target cells in the optic lobe. Here we investigate the role of the Netrins and their receptor Frazzled in the establishment of retinal projections. We find that the Netrins, although expressed in the target, are not required for retinal projections. Surprisingly, Frazzled, found on both retinal fibers and target cells, is required in the target for attracting retinal fibers, while playing at best a redundant role in the retinal fibers themselves; this finding demonstrates that target attraction is necessary for topographic map formation. Finally, we show that Frazzled is not required for the differentiation of cells in the target. Our data suggest that Frazzled does not function as a Netrin receptor in attracting retinal fibers to the target; nor does it seem to act as a homotypic cell adhesion molecule. We favor the possibility that Frazzled in the target interacts with a component on the surface of retinal fibers, possibly another Netrin receptor.",
keywords = "Drosophila, Frazzled, Netrin, Retinal projection, Topographic map formation, Visual system development",
author = "Qizhi Gong and Radha Rangarajan and Mark Seeger and Ulrike Gaul",
year = "1999",
month = "4",
language = "English (US)",
volume = "126",
pages = "1451--1456",
journal = "Development (Cambridge)",
issn = "0950-1991",
publisher = "Company of Biologists Ltd",
number = "7",

}

TY - JOUR

T1 - The Netrin receptor Frazzled is required in the target for establishment of retinal projections in the Drosophila visual system

AU - Gong, Qizhi

AU - Rangarajan, Radha

AU - Seeger, Mark

AU - Gaul, Ulrike

PY - 1999/4

Y1 - 1999/4

N2 - Retinal axons in Drosophila make precise topographic connections with their target cells in the optic lobe. Here we investigate the role of the Netrins and their receptor Frazzled in the establishment of retinal projections. We find that the Netrins, although expressed in the target, are not required for retinal projections. Surprisingly, Frazzled, found on both retinal fibers and target cells, is required in the target for attracting retinal fibers, while playing at best a redundant role in the retinal fibers themselves; this finding demonstrates that target attraction is necessary for topographic map formation. Finally, we show that Frazzled is not required for the differentiation of cells in the target. Our data suggest that Frazzled does not function as a Netrin receptor in attracting retinal fibers to the target; nor does it seem to act as a homotypic cell adhesion molecule. We favor the possibility that Frazzled in the target interacts with a component on the surface of retinal fibers, possibly another Netrin receptor.

AB - Retinal axons in Drosophila make precise topographic connections with their target cells in the optic lobe. Here we investigate the role of the Netrins and their receptor Frazzled in the establishment of retinal projections. We find that the Netrins, although expressed in the target, are not required for retinal projections. Surprisingly, Frazzled, found on both retinal fibers and target cells, is required in the target for attracting retinal fibers, while playing at best a redundant role in the retinal fibers themselves; this finding demonstrates that target attraction is necessary for topographic map formation. Finally, we show that Frazzled is not required for the differentiation of cells in the target. Our data suggest that Frazzled does not function as a Netrin receptor in attracting retinal fibers to the target; nor does it seem to act as a homotypic cell adhesion molecule. We favor the possibility that Frazzled in the target interacts with a component on the surface of retinal fibers, possibly another Netrin receptor.

KW - Drosophila

KW - Frazzled

KW - Netrin

KW - Retinal projection

KW - Topographic map formation

KW - Visual system development

UR - http://www.scopus.com/inward/record.url?scp=0032914453&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032914453&partnerID=8YFLogxK

M3 - Article

VL - 126

SP - 1451

EP - 1456

JO - Development (Cambridge)

JF - Development (Cambridge)

SN - 0950-1991

IS - 7

ER -