Abstract
Many cardiac electrophysiological abnormalities are accompanied by autonomic nervous system dysfunction. Here, we review mechanisms by which the cardiac nervous system controls normal and abnormal excitability and may contribute to atrial and ventricular tachyarrhythmias. Moreover, we explore the potential antiarrhythmic and/or arrhythmogenic effects of modulating the autonomic nervous system by several strategies, including ganglionated plexi ablation, vagal and spinal cord stimulations, and renal sympathetic denervation as therapies for atrial and ventricular arrhythmias.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 199-209 |
| Number of pages | 11 |
| Journal | Progress in Biophysics and Molecular Biology |
| Volume | 120 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - Jan 1 2016 |
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Keywords
- Atrial fibrillation
- Autonomic control
- Cardiac nerves
- Ventricular tachycardia/fibrillation
ASJC Scopus subject areas
- Molecular Biology
- Biophysics
Cite this
The nervous heart. / Ripplinger, Crystal M; Noujaim, Sami F.; Linz, Dominik.
In: Progress in Biophysics and Molecular Biology, Vol. 120, No. 1-3, 01.01.2016, p. 199-209.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The nervous heart
AU - Ripplinger, Crystal M
AU - Noujaim, Sami F.
AU - Linz, Dominik
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Many cardiac electrophysiological abnormalities are accompanied by autonomic nervous system dysfunction. Here, we review mechanisms by which the cardiac nervous system controls normal and abnormal excitability and may contribute to atrial and ventricular tachyarrhythmias. Moreover, we explore the potential antiarrhythmic and/or arrhythmogenic effects of modulating the autonomic nervous system by several strategies, including ganglionated plexi ablation, vagal and spinal cord stimulations, and renal sympathetic denervation as therapies for atrial and ventricular arrhythmias.
AB - Many cardiac electrophysiological abnormalities are accompanied by autonomic nervous system dysfunction. Here, we review mechanisms by which the cardiac nervous system controls normal and abnormal excitability and may contribute to atrial and ventricular tachyarrhythmias. Moreover, we explore the potential antiarrhythmic and/or arrhythmogenic effects of modulating the autonomic nervous system by several strategies, including ganglionated plexi ablation, vagal and spinal cord stimulations, and renal sympathetic denervation as therapies for atrial and ventricular arrhythmias.
KW - Atrial fibrillation
KW - Autonomic control
KW - Cardiac nerves
KW - Ventricular tachycardia/fibrillation
UR - http://www.scopus.com/inward/record.url?scp=84955315013&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955315013&partnerID=8YFLogxK
U2 - 10.1016/j.pbiomolbio.2015.12.015
DO - 10.1016/j.pbiomolbio.2015.12.015
M3 - Article
C2 - 26780507
AN - SCOPUS:84955315013
VL - 120
SP - 199
EP - 209
JO - Progress in Biophysics and Molecular Biology
JF - Progress in Biophysics and Molecular Biology
SN - 0079-6107
IS - 1-3
ER -