The nervous heart

Crystal M Ripplinger, Sami F. Noujaim, Dominik Linz

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Many cardiac electrophysiological abnormalities are accompanied by autonomic nervous system dysfunction. Here, we review mechanisms by which the cardiac nervous system controls normal and abnormal excitability and may contribute to atrial and ventricular tachyarrhythmias. Moreover, we explore the potential antiarrhythmic and/or arrhythmogenic effects of modulating the autonomic nervous system by several strategies, including ganglionated plexi ablation, vagal and spinal cord stimulations, and renal sympathetic denervation as therapies for atrial and ventricular arrhythmias.

Original languageEnglish (US)
Pages (from-to)199-209
Number of pages11
JournalProgress in Biophysics and Molecular Biology
Issue number1-3
StatePublished - Jan 1 2016


  • Atrial fibrillation
  • Autonomic control
  • Cardiac nerves
  • Ventricular tachycardia/fibrillation

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics


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