The nervous heart

Crystal M Ripplinger; Sami F. Noujaim; Dominik Linz

doi:10.1016/j.pbiomolbio.2015.12.015

The nervous heart

Crystal M Ripplinger, Sami F. Noujaim, Dominik Linz

Pharmacology

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

Many cardiac electrophysiological abnormalities are accompanied by autonomic nervous system dysfunction. Here, we review mechanisms by which the cardiac nervous system controls normal and abnormal excitability and may contribute to atrial and ventricular tachyarrhythmias. Moreover, we explore the potential antiarrhythmic and/or arrhythmogenic effects of modulating the autonomic nervous system by several strategies, including ganglionated plexi ablation, vagal and spinal cord stimulations, and renal sympathetic denervation as therapies for atrial and ventricular arrhythmias.

Original language	English (US)
Pages (from-to)	199-209
Number of pages	11
Journal	Progress in Biophysics and Molecular Biology
Volume	120
Issue number	1-3
DOIs	https://doi.org/10.1016/j.pbiomolbio.2015.12.015
State	Published - Jan 1 2016

Keywords

Atrial fibrillation
Autonomic control
Cardiac nerves
Ventricular tachycardia/fibrillation

ASJC Scopus subject areas

Molecular Biology
Biophysics

Access to Document

10.1016/j.pbiomolbio.2015.12.015

Fingerprint Dive into the research topics of 'The nervous heart'. Together they form a unique fingerprint.

Cite this

@article{d83a5acb1df74ea8ba99610ee1135a6a,

title = "The nervous heart",

abstract = "Many cardiac electrophysiological abnormalities are accompanied by autonomic nervous system dysfunction. Here, we review mechanisms by which the cardiac nervous system controls normal and abnormal excitability and may contribute to atrial and ventricular tachyarrhythmias. Moreover, we explore the potential antiarrhythmic and/or arrhythmogenic effects of modulating the autonomic nervous system by several strategies, including ganglionated plexi ablation, vagal and spinal cord stimulations, and renal sympathetic denervation as therapies for atrial and ventricular arrhythmias.",

keywords = "Atrial fibrillation, Autonomic control, Cardiac nerves, Ventricular tachycardia/fibrillation",

author = "Ripplinger, {Crystal M} and Noujaim, {Sami F.} and Dominik Linz",

year = "2016",

month = jan,

day = "1",

doi = "10.1016/j.pbiomolbio.2015.12.015",

language = "English (US)",

volume = "120",

pages = "199--209",

journal = "Progress in Biophysics and Molecular Biology",

issn = "0079-6107",

publisher = "Elsevier Limited",

number = "1-3",

}

TY - JOUR

T1 - The nervous heart

AU - Ripplinger, Crystal M

AU - Noujaim, Sami F.

AU - Linz, Dominik

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Many cardiac electrophysiological abnormalities are accompanied by autonomic nervous system dysfunction. Here, we review mechanisms by which the cardiac nervous system controls normal and abnormal excitability and may contribute to atrial and ventricular tachyarrhythmias. Moreover, we explore the potential antiarrhythmic and/or arrhythmogenic effects of modulating the autonomic nervous system by several strategies, including ganglionated plexi ablation, vagal and spinal cord stimulations, and renal sympathetic denervation as therapies for atrial and ventricular arrhythmias.

AB - Many cardiac electrophysiological abnormalities are accompanied by autonomic nervous system dysfunction. Here, we review mechanisms by which the cardiac nervous system controls normal and abnormal excitability and may contribute to atrial and ventricular tachyarrhythmias. Moreover, we explore the potential antiarrhythmic and/or arrhythmogenic effects of modulating the autonomic nervous system by several strategies, including ganglionated plexi ablation, vagal and spinal cord stimulations, and renal sympathetic denervation as therapies for atrial and ventricular arrhythmias.

KW - Atrial fibrillation

KW - Autonomic control

KW - Cardiac nerves

KW - Ventricular tachycardia/fibrillation

UR - http://www.scopus.com/inward/record.url?scp=84955315013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955315013&partnerID=8YFLogxK

U2 - 10.1016/j.pbiomolbio.2015.12.015

DO - 10.1016/j.pbiomolbio.2015.12.015

M3 - Article

C2 - 26780507

AN - SCOPUS:84955315013

VL - 120

SP - 199

EP - 209

JO - Progress in Biophysics and Molecular Biology

JF - Progress in Biophysics and Molecular Biology

SN - 0079-6107

IS - 1-3

ER -

The nervous heart

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this