The nervous heart

Crystal M Ripplinger; Sami F. Noujaim; Dominik Linz

doi:10.1016/j.pbiomolbio.2015.12.015

The nervous heart

Crystal M Ripplinger, Sami F. Noujaim, Dominik Linz

Pharmacology

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Many cardiac electrophysiological abnormalities are accompanied by autonomic nervous system dysfunction. Here, we review mechanisms by which the cardiac nervous system controls normal and abnormal excitability and may contribute to atrial and ventricular tachyarrhythmias. Moreover, we explore the potential antiarrhythmic and/or arrhythmogenic effects of modulating the autonomic nervous system by several strategies, including ganglionated plexi ablation, vagal and spinal cord stimulations, and renal sympathetic denervation as therapies for atrial and ventricular arrhythmias.

Original language	English (US)
Pages (from-to)	199-209
Number of pages	11
Journal	Progress in Biophysics and Molecular Biology
Volume	120
Issue number	1-3
DOIs	https://doi.org/10.1016/j.pbiomolbio.2015.12.015
State	Published - Jan 1 2016

Keywords

Atrial fibrillation
Autonomic control
Cardiac nerves
Ventricular tachycardia/fibrillation

ASJC Scopus subject areas

Molecular Biology
Biophysics

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10.1016/j.pbiomolbio.2015.12.015

Cite this

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AU - Ripplinger, Crystal M

AU - Noujaim, Sami F.

AU - Linz, Dominik

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N2 - Many cardiac electrophysiological abnormalities are accompanied by autonomic nervous system dysfunction. Here, we review mechanisms by which the cardiac nervous system controls normal and abnormal excitability and may contribute to atrial and ventricular tachyarrhythmias. Moreover, we explore the potential antiarrhythmic and/or arrhythmogenic effects of modulating the autonomic nervous system by several strategies, including ganglionated plexi ablation, vagal and spinal cord stimulations, and renal sympathetic denervation as therapies for atrial and ventricular arrhythmias.

AB - Many cardiac electrophysiological abnormalities are accompanied by autonomic nervous system dysfunction. Here, we review mechanisms by which the cardiac nervous system controls normal and abnormal excitability and may contribute to atrial and ventricular tachyarrhythmias. Moreover, we explore the potential antiarrhythmic and/or arrhythmogenic effects of modulating the autonomic nervous system by several strategies, including ganglionated plexi ablation, vagal and spinal cord stimulations, and renal sympathetic denervation as therapies for atrial and ventricular arrhythmias.

KW - Atrial fibrillation

KW - Autonomic control

KW - Cardiac nerves

KW - Ventricular tachycardia/fibrillation

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The nervous heart

Abstract

Keywords

ASJC Scopus subject areas

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