The myth of the 50-50 breast

M. J. Yaffe, John M Boone, N. Packard, O. Alonzo-Proulx, S. Y. Huang, C. L. Peressotti, A. Al-Mayah, K. Brock

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

Purpose: For dosimetry and for work in optimization of x-ray imaging of the breast, it is commonly assumed that the breast is composed of 50% fibroglandular tissue and 50% fat. The purpose of this study was to assess whether this assumption was realistic. Methods: First, data obtained from an experimental breast CT scanner were used to validate an algorithm that measures breast density from digitized film mammograms. Density results obtained from a total of 2831 women, including 191 women receiving CT and from mammograms of 2640 women from three other groups, were then used to estimate breast compositions. Results: Mean compositions, expressed as percent fibroglandular tissue (including the skin), varied from 13.7% to 25.6% among the groups with an overall mean of 19.3%. The mean compressed breast thickness for the mammograms was 5.9 cm (σ=1.6 cm). 80% of the women in our study had volumetric breast density less than 27% and 95% were below 45%. Conclusions: Based on the results obtained from the four groups of women in our study, the "50-50" breast is not a representative model of the breast composition.

Original languageEnglish (US)
Pages (from-to)5437-5443
Number of pages7
JournalMedical Physics
Volume36
Issue number12
DOIs
StatePublished - 2009

Fingerprint

Breast
Fats
X-Rays
Skin
Breast Density

Keywords

  • Breast composition
  • Breast CT
  • Breast density
  • Dosimetry
  • Mammography
  • Mean glandular dose

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Yaffe, M. J., Boone, J. M., Packard, N., Alonzo-Proulx, O., Huang, S. Y., Peressotti, C. L., ... Brock, K. (2009). The myth of the 50-50 breast. Medical Physics, 36(12), 5437-5443. https://doi.org/10.1118/1.3250863

The myth of the 50-50 breast. / Yaffe, M. J.; Boone, John M; Packard, N.; Alonzo-Proulx, O.; Huang, S. Y.; Peressotti, C. L.; Al-Mayah, A.; Brock, K.

In: Medical Physics, Vol. 36, No. 12, 2009, p. 5437-5443.

Research output: Contribution to journalArticle

Yaffe, MJ, Boone, JM, Packard, N, Alonzo-Proulx, O, Huang, SY, Peressotti, CL, Al-Mayah, A & Brock, K 2009, 'The myth of the 50-50 breast', Medical Physics, vol. 36, no. 12, pp. 5437-5443. https://doi.org/10.1118/1.3250863
Yaffe MJ, Boone JM, Packard N, Alonzo-Proulx O, Huang SY, Peressotti CL et al. The myth of the 50-50 breast. Medical Physics. 2009;36(12):5437-5443. https://doi.org/10.1118/1.3250863
Yaffe, M. J. ; Boone, John M ; Packard, N. ; Alonzo-Proulx, O. ; Huang, S. Y. ; Peressotti, C. L. ; Al-Mayah, A. ; Brock, K. / The myth of the 50-50 breast. In: Medical Physics. 2009 ; Vol. 36, No. 12. pp. 5437-5443.
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