The Mutation Frequency of Feline Immunodeficiency Virus Enhanced by 3′-Azido-3′-deoxythymidine

Rachel A. LaCasse, Kathryn M. Remington, Thomas W. North

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We have developed a host range system to measure the mutation frequency of feline immunodeficiency virus (FIV), the feline homologue of human immunodeficiency virus type 1 (HIV-1). When wild-type FIV was grown in the presence of a known mutagen, 5-bromo-2′-deoxyuridine (BUdR), a dose-dependent increase of host range mutants was detected. Using this system, we have evaluated the effects of antiviral drugs upon the mutation frequency of FIV. Subinhibitory concentrations of 3′-azido-3′-deoxythymidine (AZT), the most common antiviral drug used in AIDS chemotherapy, increased the mutation frequency of FIV in a dose-dependent manner. Two other antivirals, 2′,3′-dideoxyinosine (ddI) and 2′,3′-dideoxycytidine (ddC), did not show this effect.

Original languageEnglish (US)
Pages (from-to)26-32
Number of pages7
JournalJournal of Acquired Immune Deficiency Syndromes
Volume12
Issue number1
StatePublished - 1996
Externally publishedYes

Keywords

  • Antiviral drugs
  • Feline immunodeficiency virus
  • Lentivirus mutation frequency

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Immunology and Allergy

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