The mouse genome encodes a single homolog of the antimicrobial peptide human β-defensin 1

Kenneth M. Huttner, Christine A. Kozak, Charles L Bevins

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

The cysteine-rich β-defensin peptides are broad-spectrum bactericidal agents expressed in epithelial and myeloid tissues. The human β-defensin-1 (hBD-1) gene maps adjacent to the human α-defensin cluster and is expressed in the respiratory, gastrointestinal and genitourinary tracts. Here, we characterize a mouse β-defensin gene (mBD-1) which is: (1) closely related to hBD-1 both in sequence and gene organization; (2) expressed at high levels in the mouse kidney and at lower levels in brain, heart, lung, uterus, spleen, skeletal muscle, stomach, and small intestine; and (3) maps to mouse chromosome 8 at or near the location of the mouse α-defensin genes. These data indicate that mBD-1 is a close homolog of hBD-1, and suggest that analysis of its role in mouse host defense may provide significant insights into human epithelial innate immunity.

Original languageEnglish (US)
Pages (from-to)45-49
Number of pages5
JournalFEBS Letters
Volume413
Issue number1
DOIs
StatePublished - Aug 11 1997
Externally publishedYes

Fingerprint

Defensins
Genes
Genome
Peptides
Chromosomes, Human, Pair 8
Chromosomes
Innate Immunity
Small Intestine
Uterus
Cysteine
Muscle
Gastrointestinal Tract
Brain
Stomach
Skeletal Muscle
Spleen
Epithelium
Tissue
Kidney
Lung

Keywords

  • Antimicrobial peptide
  • Defensin
  • Mouse

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

The mouse genome encodes a single homolog of the antimicrobial peptide human β-defensin 1. / Huttner, Kenneth M.; Kozak, Christine A.; Bevins, Charles L.

In: FEBS Letters, Vol. 413, No. 1, 11.08.1997, p. 45-49.

Research output: Contribution to journalArticle

Huttner, Kenneth M. ; Kozak, Christine A. ; Bevins, Charles L. / The mouse genome encodes a single homolog of the antimicrobial peptide human β-defensin 1. In: FEBS Letters. 1997 ; Vol. 413, No. 1. pp. 45-49.
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