The mouse genome encodes a single homolog of the antimicrobial peptide human β-defensin 1

Kenneth M. Huttner, Christine A. Kozak, Charles L Bevins

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

The cysteine-rich β-defensin peptides are broad-spectrum bactericidal agents expressed in epithelial and myeloid tissues. The human β-defensin-1 (hBD-1) gene maps adjacent to the human α-defensin cluster and is expressed in the respiratory, gastrointestinal and genitourinary tracts. Here, we characterize a mouse β-defensin gene (mBD-1) which is: (1) closely related to hBD-1 both in sequence and gene organization; (2) expressed at high levels in the mouse kidney and at lower levels in brain, heart, lung, uterus, spleen, skeletal muscle, stomach, and small intestine; and (3) maps to mouse chromosome 8 at or near the location of the mouse α-defensin genes. These data indicate that mBD-1 is a close homolog of hBD-1, and suggest that analysis of its role in mouse host defense may provide significant insights into human epithelial innate immunity.

Original languageEnglish (US)
Pages (from-to)45-49
Number of pages5
JournalFEBS Letters
Volume413
Issue number1
DOIs
StatePublished - Aug 11 1997
Externally publishedYes

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Keywords

  • Antimicrobial peptide
  • Defensin
  • Mouse

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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