The molecular oncology of bilateral high-grade thalamic astrocytomas in children

Amir Goodarzi, Nicholas Garza, Mirna Lechpammer, Reuben Anthony, Marike Zwienenberg

Research output: Contribution to journalArticle

Abstract

Background: Bilateral thalamic astrocytomas in children are exceedingly rare. These highly malignant tumors seldom respond to conventional treatment strategies and carry a grim prognosis for patients. However, recent advances in molecular oncology have had a positive impact on prognostication and treatment strategies of these tumors. Case-based review: We present a new case of WHO grade III bilateral thalamic astrocytoma in a child and review the pathophysiology, molecular oncogenesis, and relevant treatment strategies for this rare disease. Conclusions: High-grade thalamic astrocytomas affecting both thalami pose a challenge to pediatric neurosurgeons, neuro-oncologists, and neuropathologists given the lack of effective treatment strategies. Understanding recent revelations in the field of molecular oncology can assist clinicians in adequately formulating a treatment plan in this patient population.

Original languageEnglish (US)
Pages (from-to)2047-2054
Number of pages8
JournalChild's Nervous System
Volume35
Issue number11
DOIs
StatePublished - Nov 1 2019

Keywords

  • Glioma
  • Histones
  • Molecular
  • Oncology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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